Fractal dimension analysis of grey matter in multiple sclerosis
Fractal dimension analysis of grey matter in multiple sclerosis
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DOI：
10.1016/j.jns.2008.12.023
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发表时间：
2009-07-15
影响因子：
4.4
通讯作者：
Villoslada, Pablo
中科院分区：
文献类型：
--
作者：
Esteban, Francisco J.;Sepulcre, Jorge;Villoslada, Pablo
分形维数（FD）是表征复杂物体形态变异性的定量参数。在其他应用中，FD已被用于在常规磁共振成像（MRI）中识别人脑的异常，包括患有多发性硬化（MS）的患者中的白色物质异常。广泛的灰质（GM）病理学最近已被确定在MS中，它似乎是长期残疾的一个关键因素。目前的工作的目的是评估是否FD测量GM在T1 MRI序列调用识别GM异常MS患者在疾病的早期阶段。一个基于体素的形态学方法优化MS被用来获得分割的大脑，在那里我们后来计算的三维FD的GM在MS患者和健康对照。我们发现MS患者与对照组相比，GM的FD显著增加。这种差异存在，即使在患者病程短，包括首次发作的MS患者。此外，FD的GM与T1和T2病变负荷，但不与GM萎缩或残疾。FD异常的GM这里检测到不同于以前发表的FD的白色物质在MS中，这表明不同的病理过程发生在每个结构。这些结果表明，GM形态异常MS患者，这种改变出现在病程的早期。(C)2008 Elsevier B.V.保留所有权利。
The fractal dimension (FD) is a quantitative parameter that characterizes the morphometric variability of a complex object. Among other applications, FD has been used to identify abnormalities of the human brain in conventional magnetic resonance imaging (MRI), including white matter abnormalities in patients with Multiple Sclerosis (MS). Extensive grey matter (GM) pathology has been recently identified in MS and it appears to be a key factor in long-term disability. The aim of the present work was to assess whether FD measurement of GM in T1 MRI sequences call identify GM abnormalities in patients with MS in the early phase of the disease. A voxel-based morphometry approach optimized for MS was used to obtain the segmented brain, where we later calculated the three-dimensional FD of the GM in MS patients and healthy controls. We found that patients with MS had a significant increase in the FD of the GM compared to controls. Such differences were present even in patients with short disease durations, including patients with first attacks of MS. In addition, the FD of the GM correlated with T1 and T2 lesion load, but not with GM atrophy or disability. The FD abnormalities of the GM here detected differed from the previously published FD of the white matter in MS, suggesting that different pathological processes were taking place in each structure. These results indicate that GM morphology is abnormal in patients with MS and that this alteration appears early in the course of the disease. (C) 2008 Elsevier B.V. All rights reserved.