Can we predict amyloid deposition by objective cognition and regional cerebral blood flow in patients with subjective cognitive decline?
Can we predict amyloid deposition by objective cognition and regional cerebral blood flow in patients with subjective cognitive decline?
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DOI：
10.1111/psyg.12397
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发表时间：
2019-07-01
期刊：
影响因子：
2
通讯作者：
Tabuchi, Hajime
中科院分区：
文献类型：
--
作者：
Funaki, Kei;Nakajima, Shinichiro;Tabuchi, Hajime
背景主观认知功能下降(SCD)可能是阿尔茨海默病(AD)的首发症状，而β-淀粉样蛋白(A-β)沉积的个体被认为是AD的高危人群。最近，淀粉样蛋白正电子发射断层扫描(PET)研究显示，Aβ阳性和阴性SCD的临床和认知特征存在差异，但它们的差异细节尚不清楚。我们的目的是调查SCD患者的Aβ沉积、临床和认知特征之间的关系。方法对42例SCD患者(女性22例，年龄74.5+/-4.7岁)进行18氟倍他滨PET检查，分为Aβ阳性组(n=10)和阴性组(n=32)。我们比较了两组的认知和心理结果，以及单光子发射计算机断层扫描(SPECT)成像数据。此外，还进行了线性回归分析，以评估SCD的严重程度与神经心理测试、情感评分和人口统计因素之间的关系。结果修订后的韦氏记忆量表逻辑记忆分测验中，即刻回忆到延迟回忆的变化率两组间差异有统计学意义(P=0.04)。然而，二分类Logistic回归分析显示，两者之间没有显著差异。此外，女性SCD的严重程度显著高于女性(P=0.002)。此外，在Aβ阴性组中，主观记忆丧失与词汇流利性类别得分(P=0.023)和淡漠程度(P=0.037)相关。结论Aβ阳性与阴性SCD在神经心理指标、临床指标和SPECT显像方面均无显著差异。此外，SCD的严重程度不能通过焦虑、抑郁或神经心理学检查来预测。
Background Subjective cognitive decline (SCD) may herald the first symptoms of Alzheimer's disease (AD) whereas individuals with beta-amyloid (A beta) deposition are regarded as a high-risk group for AD. Recently, amyloid positron emission tomography (PET) studies have demonstrated clinical and cognitive feature differences between A beta-positive and negative SCD, but details of their differences remain unclear. We aimed to investigate the relationships among A beta deposition, clinical, and cognitive features in patients with SCD. Methods Forty-two patients with SCD (22 women, 74.5 +/- 4.7 years) were examined using fluorine-18 florbetaben PET and were divided into A beta-positive (n = 10) and negative (n = 32) groups. We compared cognitive and psychological outcomes, and single photon emission computed tomography (SPECT) imaging data between the two groups. In addition, a linear regression analysis was performed to assess relationships between the severity of SCD and neuropsychological tests, affective scores, and demographic factors. Results The rate of score changes from the immediate recall to delayed recall in the logical memory subtest of the Wechsler's Memory Scale Revised were different between the groups (P = 0.04). However, the binary logistic regression analysis showed no significant differences between the two. In addition, the severity of SCD was significantly strong in women (P = 0.002). Furthermore, within the A beta-negative group, subjective memory loss correlated with word fluency category score (P = 0.023) and apathy scale (P = 0.037). Conclusions No significant differences were observed between A beta-positive and -negative SCD on any of the neuropsychological measures, clinical measures, or SPECT imaging. Further, the severity of SCD was not predicted by the symptoms of anxiety, depression, or neuropsychological examination.