REACTIONS OF THE IMMUNE-SYSTEM IN CHRONIC DEGENERATIVE NEUROLOGICAL DISEASES
REACTIONS OF THE IMMUNE-SYSTEM IN CHRONIC DEGENERATIVE NEUROLOGICAL DISEASES
复制标题
DOI：
10.1017/s0317167100032479
复制
发表时间：
1991-08-01
影响因子：
3
通讯作者：
AKIYAMA, H
中科院分区：
文献类型：
--
作者：
MCGEER, PL;MCGEER, EG;AKIYAMA, H
在肌萎缩性侧索硬化症（ALS）脊髓和阿尔茨海默病（AD）海马中，通过化学方法鉴定了与细胞介导的免疫反应一致的元素。 在这两种疾病的受影响的组织中检测到T辅助/诱导和细胞毒性/抑制淋巴细胞。 此外，发现大量反应性小胶质细胞表达主要组织相容性糖蛋白HLA-A、B、C和HLA-DR，以及Fc链（Fc-γ-R1）、补体3和4以及玻连蛋白的受体。 在AD中，补体蛋白C1 q、C4d、C3 d和C5 b-9被发现存在于营养不良的神经突、神经桩丝和一些神经纤维缠结上。 在ALS中，唯一鉴定的补体蛋白是C4d和C3 d。 整合素配体玻连蛋白和ICAM-1也被确定在这两种疾病的受影响的组织。
Elements consistent with a cell mediated immune response were identified immunohistochemically in amyotrophic lateral sclerosis (ALS) spinal cord and Alzheimer disease (AD) hippocampus. T helper/inducer and cytotoxic/suppressor lymphocytes were detected in affected tissues in both diseases. In addition, abundant reactive microglia were found expressing the major histocompatibility glycoproteins HLA-A,B,C and HLA-DR, as well as receptors for the Fc chain (Fc-gamma-Rl), for complement 3 and 4, and for vitronectin. In AD, the complement proteins C1q, C4d, C3d and C5b-9 were found on dystrophic neurites, neuropile threads and some neurofibrillary tangles. In ALS, the only complement proteins identified were C4d and C3d. The integrin ligands vitronectin and ICAM-1 were also identified in affected tissues in both diseases.