Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
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DOI：
10.1038/ng1404
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发表时间：
2004-09-01
期刊：
影响因子：
30.8
通讯作者：
Hartenstein, V
中科院分区：
文献类型：
--
作者：
Mandal, L;Banerjee, U;Hartenstein, V
果蝇淋巴腺是一个造血器官（1），与潜在的血管细胞（成心细胞）和排泄细胞（心包肾细胞）一起，起源于心源性中胚层。克隆分析为成血管细胞（2，3）提供了证据，该成血管细胞可以产生两个子细胞：一个分化成心脏或主动脉，另一个分化成血液。此外，由十肢麻痹（Dpp）、成纤维细胞生长因子（FGF）、无翅（Wg）和Notch信号传导的会聚控制的加塔因子基因pannier（pnr）和同源框基因tinman（tin）是所有心源性中胚层（包括淋巴腺）发育所需的。在这里，我们表明，一个重要的基因开关，区分血液或肾细胞和血管谱系涉及Notch途径。通过淋巴腺原基中加塔因子Serpent（Srp）的特异性表达，发生进一步的特化。我们的研究结果表明，在D。黑腹动物心源性中胚层和在哺乳动物性腺-中肾中胚层中起作用的那些（4）。
The Drosophila melanogaster lymph gland is a hematopoietic organ(1) and, together with prospective vascular cells (cardioblasts) and excretory cells (pericardial nephrocytes), arises from the cardiogenic mesoderm. Clonal analysis provided evidence for a hemangioblast(2,3) that can give rise to two daughter cells: one that differentiates into heart or aorta and another that differentiates into blood. In addition, the GATA factor gene pannier (pnr) and the homeobox gene tinman (tin), which are controlled by the convergence of Decapentaplegic (Dpp), fibroblast growth factor (FGF), Wingless (Wg) and Notch signaling, are required for the development of all cardiogenic mesoderm, including the lymph gland. Here we show that an essential genetic switch that differentiates between the blood or nephrocyte and vascular lineages involves the Notch pathway. Further specification occurs through specific expression of the GATA factor Serpent (Srp) in the lymph-gland primordium. Our findings suggest that there is a close parallel between the molecular mechanisms functioning in the D. melanogaster cardiogenic mesoderm and those functioning in the mammalian aorta-gonadal-mesonephros mesoderm(4).