Tissue resident regulatory T cells: novel therapeutic targets for human disease.
Tissue resident regulatory T cells: novel therapeutic targets for human disease.
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组织驻留调节性 T 细胞：人类疾病的新治疗靶点
DOI：
10.1038/cmi.2015.23
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发表时间：
2015-09
影响因子：
24.1
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Zhou X;Tang J;Cao H;Fan H;Li B
在过去的十年里，调节性T细胞(Tregs)抑制多种类型免疫细胞的能力受到了极大的关注。越来越多的证据表明，组织驻留Tregs控制着其靶组织的非免疫过程，并导致了大量的人类疾病。新的组织特异性Tregs的鉴定突显了它们的异质性和复杂性。本文综述了内脏脂肪组织中CD4+Foxp3+调节性T细胞(VAT Tregs)、肌肉Tregs、骨Tregs和皮肤记忆Tregs的研究进展，重点介绍了它们在局部组织中的独特功能。这种对组织特异性Tregs的作用及其参与疾病进展的解释为发现人类疾病的潜在治疗靶点提供了新的见解。
Over the past decade, the ability of regulatory T cells (Tregs) to suppress multiple types of immune cells has received tremendous attention. Mounting evidence has revealed that tissue resident Tregs control non-immunological processes of their target tissues and contribute to a plethora of human diseases. The identification of novel tissue-specific Tregs has highlighted their heterogeneity and complexity. This review summarizes the recent findings for visceral adipose tissue CD4+ Foxp3+ regulatory T cells (VAT Tregs), muscle Tregs, bone Tregs and skin memory Tregs, with a focus on their unique functions in local tissues. This interpretation of the roles of tissue-specific Tregs and of their involvement in disease progression provides new insight into the discovery of potential therapeutic targets of human diseases.