Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus
Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus
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DOI：
10.1016/j.jaad.2008.01.012
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发表时间：
2008-06-01
影响因子：
13.8
通讯作者：
Werth, Victoria P.
中科院分区：
文献类型：
--
作者：
Murrell, Dedee E.;Dick, Sarah;Werth, Victoria P.
近年来，我们对天疱疮的科学知识有了巨大的进步。然而，尽管炎性疾病的治疗有多种选择，但只有少数多中心对照试验有助于确定天疱疮的有效治疗方法。比较中心间治疗结果的主要障碍是缺乏普遍接受的天疱疮患者临床评估的定义和测量。需要天疱疮的共同术语和终点，以便该领域的专家能够准确地测量和评估疾病的程度、活动、严重程度和治疗反应，从而促进和推进临床试验。这份来自国际天疱疮委员会的共识声明代表了2年的合作努力，以获得相互接受的天疱疮的共同定义。这些应有助于在未来的研究中制定一致的结果报告。
Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in pemphigus. A major obstacle in comparing therapeutic outcomes between centers is the lack of generally accepted definitions and measurements for the clinical evaluation of patients with pemphigus. Common terms and end points of pemphigus are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. This consensus statement from the International Pemphigus Committee represents 2 years of collaborative efforts to attain mutually acceptable common definitions for pemphigus. These should assist in development of consistent reporting of outcomes in future studies.