Is milk-borne insulin-like growth factor-I essential for neonatal development?
Is milk-borne insulin-like growth factor-I essential for neonatal development?
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DOI：
10.1093/jn/127.5.975s
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发表时间：
1997-05-01
影响因子：
4.2
通讯作者：
Burrin, DG
中科院分区：
文献类型：
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作者：
Burrin, DG
胰岛素样生长因子-I(IGF-I)是一种在牛奶中发现的多肽生长因子，被认为在新生儿的生长和发育中发挥功能作用，特别是在胃肠道，根据对I-125标记的IGF-I的直接示踪研究和对喂养一定剂量IGF-I的新生动物循环中IGF-I浓度的测量，大量证据表明，IGF-I的肠道吸收以及对新陈代谢和身体生长的可能影响可以忽略不计。然而，对新生动物的研究表明，口服药物剂量的IGF-I可以促进小肠粘膜的生长，而在生理范围内提供的口服IGF-I可以促进肠道乳糖酶的发育。因此，探索口服IGF-I作为对早产儿和肠道功能受损的新生儿的干预措施的临床试验似乎是有必要的。然而，乳源性IGF-I对正常健康的婴儿可能不是必需的，可能是因为内源性IGF-I为维持胃肠道结构和功能提供了足够的刺激。未来的研究应该探索内源性IGF-I的意义，以及在内源性IGF-I产生可能受到影响的病理条件下，乳源性IGF-I是否可能是重要的。
Insulin-like growth factor-I (IGF-I), a polypeptide growth factor found in milk, is hypothesized to play a functional role in the growth and development of neonates, particularly the gastrointestinal tract, Considerable evidence, based on direct tracer studies with I-125-labeled IGF-I and measurements of circulating IGF-I concentrations in neonatal animals fed a range of IGF-I doses, indicates that the intestinal absorption of IGF-I and the possible effect on metabolism and somatic growth are negligible. However, studies in neonatal animals indicate that oral administration of pharmacological doses of IGF-I increases small intestinal mucosal growth, whereas oral IGF-I provided within the physiological range may enhance the development of intestinal lactase. Therefore, clinical trials exploring the therapeutic use of oral IGF-I as an intervention for preterm neonates and those with compromised intestinal function seem warranted. However, milk-borne IGF-I may not be essential for normal healthy infants, perhaps because endogenous IGF-I provides a sufficient stimulus for maintenance of gastrointestinal structure and function. Future studies should explore the significance of endogenous IGF-I and whether milkborne IGF-I may be important under pathological conditions in which the endogenous IGF-I production may be compromised.