General Approach To Construct Azepino[2,3-b:4,5-b ']diindoles, Azocino[2,3-b:4,5-b ']diindoles, and Azonino[2,3-b:4,5-b ']diindoles via Rh(II)-Catalyzed Reactions of 3-Diazoindolin-2-imines with 3-(Bromoalkyl)indoles
General Approach To Construct Azepino[2,3-b:4,5-b ']diindoles, Azocino[2,3-b:4,5-b ']diindoles, and Azonino[2,3-b:4,5-b ']diindoles via Rh(II)-Catalyzed Reactions of 3-Diazoindolin-2-imines with 3-(Bromoalkyl)indoles
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DOI：
10.1021/acs.joc.9b01169
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发表时间：
2019
影响因子：
3.6
通讯作者：
Wang Yanguang
中科院分区：
文献类型：
--
作者：
Sheng Guorong;Li Zhenmin;Mao Jianming;Lu Ping;Wang Yanguang
Rh（II）催化了3-重氮吲哚-2-亚胺与3-（2-溴乙基）吲哚、3-（3-溴丙基）吲哚和3-（4-溴丁基）吲哚的反应，然后分别用1,8-重氮双环[5.4.0]十一-7-烯（DBU）在一锅内处理氮平[2,3-b:4,5-b ']双吲哚、偶氮基[2,3-b:4,5-b ']双吲哚和偶氮基[2,3-b:4,5-b ']双吲哚。该方法的优点是产品结构的独特性，广泛的底物范围，温和的反应条件和现成的起始材料。
Rh(II)-catalyzed reactions of 3-diazoindolin-2-imines with 3-(2-bromoethyl)indoles, 3-(3-bromopropyl)indoles, and 3-(4-bromobutyl)indoles, followed by treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in a one-pot operation furnished azepino[2,3-b:4,5-b′]diindoles, azocino[2,3-b:4,5-b′]diindoles, and azonino[2,3-b:4,5-b′]diindoles, respectively. Structural uniqueness of the products, broad substrate scope, mild reaction conditions, and readily available starting materials are the merits of this approach.