Autofluorescence Imaging of Cystoid Macular Edema in Diabetic Retinopathy
Autofluorescence Imaging of Cystoid Macular Edema in Diabetic Retinopathy
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DOI：
10.1159/000260229
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发表时间：
2010-01-01
期刊：
影响因子：
2.6
通讯作者：
Brancato, Rosario
中科院分区：
文献类型：
--
作者：
Pece, Alfredo;Isola, Vincenzo;Brancato, Rosario
目的：我们的目的是评估糖尿病视网膜病变和黄斑囊样水肿（CME）患者的眼底自发荧光（FAF）图像及其与荧光素血管造影（FA）和光学相干断层扫描（OCT）结果的相关性。研究方法：对34例糖尿病视网膜病变患者的68只眼进行了自体荧光成像检查，使用共焦扫描激光检眼镜，FA和OCT。结果如下：在第1组的44只眼（65%）中，我们确定了3种FAF模式：（1）多囊型FAF增加（57%），（2）单个囊型FAF增加（16%），（3）单囊型和多囊型FAF增加（27%）。FA和OCT显示囊性FAF增加与CME呈正相关（r = 0.95; p = 0.001）。视力丧失与囊性区域的大小无关（p = 0.83），但与显著的黄斑增厚相关（p = 0.007）。结论：共聚焦扫描激光检眼镜可以选择性地显示糖尿病CME患者的自体荧光、多小叶间隙。即使OCT仍然是评估黄斑增厚和囊肿的首选方法，FAF可能是另一种有用的简单测试，可以快速无创地区分这种实体，并且没有风险。版权所有（C）2009 S. Karger AG，巴塞尔
Aim: Our purpose was to assess fundus autofluorescence (FAF) images in patients with diabetic retinopathy and cystoid macular edema (CME) and their correlation with fluorescein angiography (FA) and optical coherence tomography (OCT) findings. Methods: Sixty-eight eyes of 34 consecutive patients with diabetic retinopathy were examined with autofluorescence imaging using a confocal scanning laser ophthalmoscope, FA and OCT. The eyes were divided into 2 groups, group 1 with CME and group 2 without. Results: In the 44 eyes of group 1 (65% of the series), we identified 3 patterns of FAF: (1) multicystic increased FA (57%), (2) a single cyst of increased FAF (16%), (3) combined single-and multicystic increased FAF (27%). FA and OCT gave a positive correlation between cystic increased FAF and CME (r = 0.95; p = 0.001). Visual acuity loss was not correlated with the size of the cystic area (p = 0.83), but it was related to significant macular thickening (p = 0.007). Conclusions: Confocal scanning laser ophthalmoscopy can selectively visualize auto-fluorescent, multilobulated spaces in eyes with diabetic CME. Even if OCT remains preferable for evaluating macular thickening and cysts, FAF might be another useful easy test to rapidly distinguish this entity noninvasively and with no risk. Copyright (C) 2009 S. Karger AG, Basel