Age, Atrial Fibrillation, and Structural Heart Disease Are the Main Determinants of Left Atrial Fibrosis Detected by Delayed-Enhanced Magnetic Resonance Imaging in a General Cardiology Population
Age, Atrial Fibrillation, and Structural Heart Disease Are the Main Determinants of Left Atrial Fibrosis Detected by Delayed-Enhanced Magnetic Resonance Imaging in a General Cardiology Population
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DOI：
10.1111/jce.12651
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发表时间：
2015-05-01
影响因子：
2.7
通讯作者：
Jais, Pierre
中科院分区：
文献类型：
--
作者：
Cochet, Hubert;Mouries, Amaury;Jais, Pierre
心房纤维化的MRI在PatientsIntroductionWe研究了延迟增强（DE）MRI在一般cardiology population.Methods和Results190名连续的心脏MRI患者进行DE成像使用自由呼吸方法的左心房（LA）纤维化的程度和分布。人群包括60例AF患者和130例无AF患者，包括75例结构性心脏病（SHD）患者。使用直方图阈值法定量DE，以壁的%表示。进行回归分析，以确定DE的预测因子。此外，DE在模板上注册以研究其在亚群中的分布。在总人群中，年龄、AF和SHD与DE独立相关。DE在无SHD或AF患者中的发生率为11.1 ± 4.7%，在SHD且无AF病史患者中为18.8 ± 7.8%，在阵发性AF患者中为22.9 ± 7.8%，在持续性AF患者中为27.8 ± 7.7%。在非AF患者中，年龄和SHD与DE独立相关。在AF患者中，女性性别和AF持续性与DE独立相关。DE分布均匀，但更频繁地检测到在后wall.ConclusionAge，AF的历史，和SHD是最强大的心房纤维化的预测因子，通过MRI检测，在一般心脏病学人群。心房纤维化主要发生在左心房后壁。
Atrial Fibrosis on MRI in PatientsIntroductionWe studied the extent and distribution of left atrial (LA) fibrosis on delayed-enhanced (DE) MRI in a general cardiology population.Methods and ResultsOne hundred ninety consecutive patients referred for cardiac MRI underwent DE imaging using a free breathing method. The population comprised 60 AF patients and 130 patients without AF, including 75 with structural heart disease (SHD). DE was quantified using histogram thresholding, expressed in % of the wall. Regression analysis was performed to identify predictors of DE. Additionally, DE was registered on a template to study its distribution in subpopulations. In the total population, age, AF, and SHD were independently associated with DE. DE was increasingly observed from 11.1 4.7% in patients with no SHD nor AF, 18.8 +/- 7.8% in SHD and no AF history, 22.9 +/- 7.8% in paroxysmal AF, to 27.8 +/- 7.7% in persistent AF. Among non-AF patients, age and SHD were independently associated with DE. Among AF patients, female gender and AF persistence were independently associated with DE. DE was variably distributed but more frequently detected in the posterior wall.ConclusionAge, history of AF, and SHD are the most powerful predictors of atrial fibrosis, as detected by MRI, in a general cardiology population. Atrial fibrosis predominates in the posterior LA wall.