INTER-HEMISPHERIC RELATIONS DURING BILATERAL SPIKE-AND-WAVE ACTIVITY
INTER-HEMISPHERIC RELATIONS DURING BILATERAL SPIKE-AND-WAVE ACTIVITY
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DOI：
10.1111/j.1528-1157.1981.tb06156.x
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发表时间：
1981-01-01
期刊：
影响因子：
5.6
通讯作者：
GOTMAN, J
中科院分区：
文献类型：
--
作者：
GOTMAN, J
研究了双侧同步棘波活动的患者双侧大脑半球同源脑电通道间的时间关系。一组(7名患者)有广泛性皮质网状癫痫，没有局部主要致痫区域的迹象。在第二组患者(12例)中，双侧棘波活动与EEG、放射学或临床检查显示的局部致痫区域一起出现。当通道间相干性足够高时，通过将互谱的相位特性的斜率转换为时间来测量两个同源通道之间的微小时间差。虽然不是每个病例都能测量到棘波(因为相位缺乏一致性或非线性性)，但第一组的棘波和波没有明显的半球间时间差，而第二组的棘波经常从致痫区域一侧开始出现导联时间(平均15ms)。该方法可用于临床鉴别原发性和继发性双侧同步性。讨论了次级双侧同步性的概念和解释时差的可能的病理生理机制。
Temporal relationships between homologous EEG channels of the 2 hemispheres were studied in patients whose EEG showed bilateral synchronous spike-and-wave activity. One group (7 patients) had generalized corticoreticular epilepsy and no sign of a localized predominant epileptogenic area. In the 2nd group (12 patients) the bilateral spike-and-wave activity was present in conjunction with a localized area of predominant epileptogenicity demonstrated by EEG, radiological or clinical examinations. The measurement of small time differences between 2 homologous channels was performed by transforming the slope of the phase characteristic of the cross-spectrum into time, when the interchannel coherence was sufficiently high. Although measurements were not possible in every case (because of a lack of coherence or nonlinearity of the phase), the spike-and-waves in the 1st group did not present significant interhemispheric time differences, whereas those of the 2nd group frequently presented a lead time (average 15 ms) from the side with the localized epileptogenic area. The method can be clinically useful to differentiate primary from secondary bilateral synchrony. The concept of secondary bilateral synchrony and the possible pathophysiological mechanisms explaining the time differences are discussed.