Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant
Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant
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DOI：
10.1016/s0140-6736(04)15641-9
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发表时间：
2004-02-28
期刊：
影响因子：
168.9
通讯作者：
Koopmans, M
中科院分区：
文献类型：
--
作者：
Lopman, B;Vennema, H;Koopmans, M
背景高度宣传诺如病毒胃肠炎在英国和爱尔兰的医院和游轮在USA. Methods引发的猜测是否报告的活动是不寻常的，我们分析了收集的数据，通过合作研究和监测网络的病毒性胃肠炎在10个欧洲国家（英格兰和威尔士作为一个地区进行了分析）。我们按月收集了疫情总数的数据，并比较了分离病毒的基因序列。数据进行了比较，从一个系统的回顾性审查监测系统的历史数据，并与中央数据库的病毒sequence.Findings-三个地区（英格兰和威尔士，德国，荷兰）持续流行病学和病毒特征的数据，从1995年至2002年。在这三个国家中，我们注意到2002年诺如病毒爆发的显著增加，与检测和出现基因组II 4的新的主要诺如病毒变体相吻合，该变体在聚合酶基因中具有一致的突变。九个地区中有八个在2002年出现了年度高峰，在九个国家检测到了新的基因组114变异。此外，检测到的新变种之前，一个非典型的春季和夏季的爆发高峰期在三个countries.Interpretation我们的数据来自10个欧洲国家显示了显着的增加和不寻常的季节性模式诺如病毒胃肠炎在2002年发生的同时出现了一种新的遗传变异。除了显示病毒性胃肠炎爆发国际网络的附加值外，这些观察结果还提出了有关变异体生物学特性及其快速传播机制的问题。
Background Highly publicised outbreaks of norovirus gastroenteritis in hospitals in the UK and Ireland and cruise ships in the USA sparked speculation about whether this reported activity was unusual.Methods We analysed data collected through a collaborative research and surveillance network of viral gastroenteritis in ten European countries (England and Wales were analysed as one region). We compiled data on total number of outbreaks by month, and compared genetic sequences from the isolated viruses. Data were compared with historic data from a systematic retrospective review of surveillance systems and with a central database of viral sequences.Findings Three regions (England and Wales, Germany, and the Netherlands) had sustained epidemiological and viral characterisation data from 1995 to 2002. In all three, we noted a striking increase in norovirus outbreaks in 2002 that coincided with the detection and emergence of a new predominant norovirus variant of genogroup II4, which had a consistent mutation in the polymerase gene. Eight of nine regions had an annual peak in 2002 and the new genogroup 114 variant was detected in nine countries. Also, the detection of the new variant preceded an atypical spring and summer peak of outbreaks in three countries.Interpretation Our data from ten European countries show a striking increase and unusual seasonal pattern of norovirus gastroenteritis in 2002 that occurred concurrently with the emergence of a novel genetic variant. In addition to showing the added value of an international network for viral gastroenteritis outbreaks, these observations raise questions about the biological properties of the variant and the mechanisms for its rapid dissemination.