Post-oral sugar detection rapidly and chemospecifically modulates taste-guided behavior.
Post-oral sugar detection rapidly and chemospecifically modulates taste-guided behavior.
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口腔后糖检测快速并化学特异性地调节味觉引导行为。
DOI：
10.1152/ajpregu.00155.2016
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Spector,AlanC
中科院分区：
文献类型：
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作者：
Schier,LindseyA;Spector,AlanC
最近的几项研究表明，口服后的糖感测迅速刺激摄入。在这里，我们探讨的特异性与早期阶段后口服糖的感觉影响摄食动机。在实验1中，训练大鼠将0.3 M蔗糖的消耗与注射LiCl（3.0 meq/kg ip，条件性味觉厌恶）或给予同等刺激暴露相关联，但以非配对方式。然后，对所有大鼠进行两次快速接近试验，以评估对蔗糖（0.01-1.0 M）、0.12 M NaCl和dH 2 O（在随机区组的10-s试验中）味道特性的食欲和消耗反应。在每次试验前开始，给予十二指肠内输注0.3 M蔗糖或等渗0.15 M NaCl（3.0 ml）。对于未配对的大鼠，十二指肠内蔗糖特别增强舔0.03-1.0 M蔗糖，没有影响试验开始，相对于十二指肠内NaCl。正如预期的那样，厌恶蔗糖的大鼠以浓度依赖性方式抑制了对蔗糖的舔舐反应，但十二指肠内蔗糖预负荷似乎并未进一步影响舔舐反应;相反，十二指肠内蔗糖减弱了试验的启动。然而，使用系列味觉反应（TR）范式，实验2表明，十二指肠内蔗糖预负荷抑制了蔗糖厌恶大鼠对经口递送蔗糖的摄食反应。最后，实验3表明，十二指肠内蔗糖预负荷增强了对一些代表性的促味剂（蔗糖、多糖和Intradenoid）的优先舔味，但对其他促味剂（NaCl、奎宁）没有增强作用。总之，结果表明，口服后糖的早期强化功效取决于摄入物的感官和动机特性。
Several recent studies have shown that post-oral sugar sensing rapidly stimulates ingestion. Here, we explored the specificity with which early-phase post-oral sugar sensing influenced ingestive motivation. Inexperiment 1, rats were trained to associate the consumption of 0.3 M sucrose with injections of LiCl (3.0 meq/kg ip, conditioned taste aversion) or given equivalent exposures to the stimuli, but in an unpaired fashion. Then, all rats were subjected to two brief-access tests to assess appetitive and consummatory responses to the taste properties of sucrose (0.01–1.0 M), 0.12 M NaCl, and dH2O (in 10-s trials in randomized blocks). Intraduodenal infusions of either 0.3 M sucrose or equiosmolar 0.15 M NaCl (3.0 ml) were administered, beginning just before each test. For unpaired rats, intraduodenal sucrose specifically enhanced licking for 0.03–1.0 M sucrose, with no effect on trial initiation, relative to intraduodenal NaCl. Rats with an aversion to sucrose suppressed licking responses to sucrose in a concentration-dependent manner, as expected, but the intraduodenal sucrose preload did not appear to further influence licking responses; instead, intraduodenal sucrose attenuated trial initiation. Using a serial taste reactivity (TR) paradigm, however,experiment 2demonstrated that intraduodenal sucrose preloads suppressed ingestive oromotor responses to intraorally delivered sucrose in rats with a sucrose aversion. Finally,experiment 3showed that intraduodenal sucrose preloads enhanced preferential licking to some representative tastants tested (sucrose, Polycose, and Intralipid), but not others (NaCl, quinine). Together, the results suggest that the early phase-reinforcing efficacy of post-oral sugar is dependent on the sensory and motivational properties of the ingesta.