Presence of neutrophil extracellular traps in superficial venous thrombosis of Behcet’s disease
Presence of neutrophil extracellular traps in superficial venous thrombosis of Behcet’s disease
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白塞病浅静脉血栓形成中性粒细胞胞外陷阱的存在
DOI：
10.1111/1346-8138.16391
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ishizu Akihiro
中科院分区：
文献类型：
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作者：
Kawakami Tamihiro;Yokoyama Kae;Ikeda Takaharu;Nishibata Yuka;Masuda Sakiko;Tomaru Utano;Ishizu Akihiro
白塞氏病（BD）具有异质性的疾病表现谱，其特征在于累及不同器官，并且可以根据负责的临床部门而具有不同的症状。我们回顾性分析了在我院就诊的BD患者，并调查了这些患者中中性粒细胞产生中性粒细胞胞外陷阱（NET）的情况。对3名BD患者的皮肤活检组织进行髓过氧化物酶和组蛋白瓜氨酸蛋白免疫标记，这些患者在结节性红斑样病变中有皮肤活检证实的浅静脉血栓性静脉炎。我们观察到在我们皮肤科就诊的BD患者中女性患者比例较高，痤疮样皮疹的发生率较高，而在其他科室治疗的BD患者中眼部和胃肠道受累的发生率较高。我们认为，性别统计趋势可能导致不同表现的共同发展，并可能帮助临床医生选择最佳的治疗方法，使其适应患者的特定表型，而不是基于单一疾病表现。NET在脂膜炎合并浅静脉血栓性静脉炎的中性粒细胞中可见。我们认为BD相关血栓形成的发病机制可能与中性粒细胞活化和NET在受累皮肤病变、结节性红斑样病变的脂膜炎中释放有关。
Behçet’s disease (BD) has a heterogeneous spectrum of disease manifestations featuring the involvement of different organs and can be characterized with different symptoms depending on the clinical department in charge. We retrospectively reviewed BD patients seen at our hospital and investigated the presence of neutrophils producing neutrophil extracellular traps (NET) in those patients. Immunolabeling of myeloperoxidase and histone citrullination proteins was performed on skin biopsies from three BD patients who had skin biopsy‐proven superficial vein thrombophlebitis in their erythema nodosum‐like lesions. We observed a higher proportion of female patients and a higher incidence of acne‐like eruptions among BD patients seen at our dermatology department, while there was a higher incidence of ocular and gastrointestinal involvement among BD patients treated in other departments. We suggest that sex statistical trends could lead to the co‐development of different manifestations and may help clinicians choose the best therapeutic approaches, tailoring them to the specific phenotype of the patient rather than one based on single disease manifestations. NET were found in neutrophils of panniculitis concurrent with superficial vein thrombophlebitis. We suggest that the pathogenesis of BD‐related thrombosis could be associated with neutrophil activation and NET are released in the panniculitis of affected skin lesions, erythema nodosum‐like lesions.