Recent advances in understanding West Nile virus host immunity and viral pathogenesis.
Recent advances in understanding West Nile virus host immunity and viral pathogenesis.
复制标题
DOI：
10.12688/f1000research.13362.1
复制
发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Wang, Tian
中科院分区：
文献类型：
--
作者：
Luo, Huanle;Wang, Tian
西尼罗河病毒（WNV）是一种蚊媒黄病毒，近二十年来一直是美国重大的公共卫生问题。该病毒与急性病毒性脑炎、神经系统后遗症和慢性肾脏疾病有关。目前人类还没有抗病毒药物和疫苗。体外细胞培养和实验动物模型已被用于研究西尼罗河病毒在人类中的感染。在这篇综述中，我们将集中在最近的研究结果，并提供新的见解西尼罗河病毒宿主免疫和病毒的发病机制。
West Nile virus (WNV), a mosquito-borne flavivirus, has been a significant public health concern in the United States for nearly two decades. The virus has been linked to acute viral encephalitis, neurological sequelae, and chronic kidney diseases. Neither antiviral drugs nor vaccines are currently available for humans. In vitro cell culture and experimental animal models have been used to study WNV infection in humans. In this review, we will focus on recent findings and provide new insights into WNV host immunity and viral pathogenesis.