Targeting the epigenome in in-stent restenosis: from mechanisms to therapy.
Targeting the epigenome in in-stent restenosis: from mechanisms to therapy.
复制标题
靶向支架内再狭窄的表观基因组：从机制到治疗
DOI：
10.1016/j.omtn.2021.01.024
复制
发表时间：
2021-03-05
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Yang X;Yang Y;Guo J;Meng Y;Li M;Yang P;Liu X;Aung LHH;Yu T;Li Y
冠状动脉疾病(CAD)是全球最常见的死亡原因之一。经皮血管重建术的引入使冠心病患者的治疗发生了革命性的变化。尽管药物洗脱支架的出现，再狭窄仍然是治疗冠心病患者的主要挑战。支架内再狭窄(ISR)是指经皮冠状动脉介入治疗后管腔直径缩小，血管内皮细胞(ECs)异常增殖、迁移和迁移所致的管腔再狭窄。越来越多的证据表明，表观遗传学参与了ISR的发生和发展。在这篇综述中，我们提供了三个独立但相关的表观遗传学机制调控ISR的最新和全面的分析，即DNA甲基化、组蛋白修饰和非编码RNA。首先，我们讨论了再狭窄的机制。此外，我们还讨论了不同的表观遗传修饰调控血管平滑肌细胞和内皮细胞在ISR中基因表达和功能的生物学机制。最后，我们讨论了心血管表观遗传因子小分子抑制剂的潜在治疗靶点。更详细地了解表观遗传调控对于阐明这一复杂的生物学过程是至关重要的，这将有助于开发和改进ISR治疗。Yang等人。综述再狭窄的表观遗传调控机制，并讨论表观遗传修饰的分子调控机制。这篇综述对再狭窄的潜在机制提供了重要的见解，并为增殖性血管疾病，特别是再狭窄提供了潜在的调控治疗靶点。
Coronary artery disease (CAD) is one of the most common causes of death worldwide. The introduction of percutaneous revascularization has revolutionized the therapy of patients with CAD. Despite the advent of drug-eluting stents, restenosis remains the main challenge in treating patients with CAD. In-stent restenosis (ISR) indicates the reduction in lumen diameter after percutaneous coronary intervention, in which the vessel’s lumen re-narrowing is attributed to the aberrant proliferation and migration of vascular smooth muscle cells (VSMCs) and dysregulation of endothelial cells (ECs). Increasing evidence has demonstrated that epigenetics is involved in the occurrence and progression of ISR. In this review, we provide the latest and comprehensive analysis of three separate but related epigenetic mechanisms regulating ISR, namely, DNA methylation, histone modification, and non-coding RNAs. Initially, we discuss the mechanism of restenosis. Furthermore, we discuss the biological mechanism underlying the diverse epigenetic modifications modulating gene expression and functions of VSMCs, as well as ECs in ISR. Finally, we discuss potential therapeutic targets of the small molecule inhibitors of cardiovascular epigenetic factors. A more detailed understanding of epigenetic regulation is essential for elucidating this complex biological process, which will assist in developing and improving ISR therapy. Yang et al. review the mechanism of epigenetic regulation of restenosis and discuss molecule regulators for epigenetic modification. This review provides important insights into the underlying mechanisms of restenosis, and it provides potential regulatory therapeutic targets for proliferative vascular diseases, especially for restenosis.
登录
查看更多内容
影响因子：
21.1
作者：
Cai J;Culley MK;Zhao Y;Zhao J
通讯作者：
Zhao J
影响因子：
3.7
作者：
Cao, ChengJian;Zhang, HuiPing;Jiang, YiDeng
通讯作者：
Jiang, YiDeng
影响因子：
20.3
作者：
Bridge, Gemma;Monteiro, Rui;Boshoff, Chris
通讯作者：
Boshoff, Chris
影响因子：
6
作者：
Bowes, Anna J.;Khan, Mohammad I.;Werstuck, Geoff H.
通讯作者：
Werstuck, Geoff H.
影响因子：
7.7
作者：
Balestrieri, Maria Luisa;Rizzo, Maria Rosaria;Marfella, Raffaele
通讯作者：
Marfella, Raffaele