The effect of vitamin D on airway reactivity and inflammation in asthmatic children: A double-blind placebo-controlled trial
The effect of vitamin D on airway reactivity and inflammation in asthmatic children: A double-blind placebo-controlled trial
复制标题
DOI：
10.1002/ppul.23076
复制
发表时间：
2015-08-01
影响因子：
3.1
通讯作者：
Bentur, Lea
中科院分区：
文献类型：
--
作者：
Bar Yoseph, Ronen;Livnat, Galit;Bentur, Lea
背景横断面研究报告了维生素 D 缺乏与哮喘患病率和严重程度增加以及过敏之间的关联。维生素 D 作为单一疗法对气道高反应性 (AHR) 和气道炎症的影响尚未见报道。目的通过乙酰甲胆碱浓度评估维生素 D 疗法对 AHR 的影响，导致 FEV1 (PC20-FEV1) 和呼出一氧化氮分数 (FeNO)、过敏和炎症的全身标志物以及呼出气冷凝细胞因子降低 20%。患者和方法儿童老年这项随机、双盲、安慰剂对照研究纳入了临床诊断为轻度哮喘、目前未接受抗炎治疗且维生素 D 水平较低的 6-18 岁患者，评估每周一次口服维生素 D 14,000 单位或安慰剂治疗 6 周的效果。结果在 39 名患者中，20 名接受维生素 D 治疗，19 名接受安慰剂。维生素 D 替代导致维生素水平显着增加，而安慰剂组则保持不变（P
BackgroundCross-sectional studies have reported an association of vitamin D deficiency with increased asthma prevalence and severity, and with allergies. The effect of vitamin D as sole therapy on airway hyper-reactivity (AHR) and airway inflammation has not been reported.AimTo evaluate the effect of vitamin D therapy on AHR as assessed by methacholine concentration, causing a 20% reduction in FEV1 (PC20-FEV1) and fractional exhaled nitric oxide (FeNO), systemic markers of allergy and inflammation, and exhaled breath condensate cytokines.Patients and MethodsChildren aged 6-18 years with a clinical diagnosis of mild asthma currently not receiving anti-inflammatory therapy and with low vitamin D levels were included in this randomized, double-blind, placebo-controlled study assessing the effect of 6 weeks of treatment with oral vitamin D 14,000 units once weekly or placebo.ResultsOf the 39 patients included, 20 received vitamin D treatment and 19 received a placebo. Vitamin D replacement resulted in a significant increase in vitamin levels, which remained unchanged in the placebo group (P