Ethanol ingestion and polyunsaturated fatty acids: effects on the acyl-CoA desaturases.
Ethanol ingestion and polyunsaturated fatty acids: effects on the acyl-CoA desaturases.
复制标题
乙醇摄入和多不饱和脂肪酸：对酰基辅酶A去饱和酶的影响。
DOI：
10.1111/j.1530-0277.1983.tb05445.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
R. Reitz
中科院分区：
文献类型：
--
作者：
Danny L Wang;R. Reitz
摄入乙醇会导致多种肝脏和脑膜中多烯脂肪酸的组成发生变化。通过测定慢性或急性处理大鼠肝微粒体中的Delta9、Delta6和Delta5酰辅酶A去饱和酶活性，研究了肝脏内质网膜这些改变的可能原因。长期来看，乙醇降低了所有三种酶的活性，其敏感性顺序如下：Delta 6(65%)，Delta 9(54%)，Delta 5(46%)。短期研究表明，饲喂乙醇1d后，三种去饱和酶活性均受到影响。慢性染毒大鼠NADPH-和NADH-细胞色素c还原酶活力降低，急性染毒大鼠NADH-细胞色素c还原酶活力降低。然而，这些酶活性的降低不能解释去饱和酶活性的下降，因为这些酶的比活性与去饱和酶之间存在非常显著的差异。因此，我们得出结论，膜多烯脂肪酸组成的变化可能是乙醇诱导的末端去饱和酶减少的结果。
The ingestion of ethanol results in altered compositions of the polyenoic fatty acids in a variety of liver and brain membranes. A possible cause for these alterations in hepatic endoplasmic reticulum membranes has been studied by measuring the delta 9, delta 6, and delta 5 acyl-CoA desaturase activities in hepatic microsomes from chronically or acutely treated rats. Chronically, ethanol decreased all three enzyme activities with the following order of sensitivity: delta 6 (65%), delta 9 (54%), and delta 5 (46%). The short-term study indicated that all three desaturase activities were affected after 1 day of ethanol feeding. NADPH- and NADH-cytochrome c reductase activities were found to be reduced in chronically treated rats, and the NADH-cytochrome c reductase was decreased in the acutely treated. However, these reduced enzyme activities could not account for the decrease in desaturase activities due to the very marked differences between the specific activities of these enzymes compared to the desaturase. Thus, we conclude that changes in membrane polyenoic fatty acid composition can be result of ethanol-induced decreases in the terminal desaturase enzymes.
影响因子：
13.6
作者：
R. Holman;S. Johnson
通讯作者：
R. Holman;S. Johnson