Comparison of the prognostic values of selected inflammation based scores in patients with medullary thyroid carcinoma: A pilot study
Comparison of the prognostic values of selected inflammation based scores in patients with medullary thyroid carcinoma: A pilot study
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DOI：
10.1002/jso.24683
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发表时间：
2017-09-01
影响因子：
2.5
通讯作者：
Zhu, Jingqiang
中科院分区：
文献类型：
--
作者：
Jiang, Ke;Lei, Jianyong;Zhu, Jingqiang
背景资料：基于炎症的评分包括嗜中性粒细胞与淋巴细胞比率（NLR）、衍生嗜中性粒细胞与淋巴细胞比率（dNLR）、血小板与淋巴细胞比率（PLR）、淋巴细胞与单核细胞比率（LMR）、预后营养指数（PNI）和血浆纤维蛋白原在甲状腺髓样癌（MTC）中的意义尚不清楚。方法：对2009年5月至2016年9月在我院行手术治疗的78例新诊断为MTC的患者进行回顾性分析。计算受试者工作特征（ROC）曲线和Kaplan-Meier分析，以比较这些评分的预后价值。结果：PLR升高是淋巴结转移的预测指标（AUC = 0.644，P = 0.022），包膜浸润（AUC = 0.666，P = 0.007）、晚期肿瘤分期（AUC = 0.657，P = 0.011）和复发（AUC = 0.655，P = 0.049）。纤维蛋白原升高可预测淋巴结转移（AUC = 0.669，P = 0.006）和包膜浸润（AUC = 0.631，P = 0.038）。PNI降低可预测复发（AUC = 0.655，P = 0.049）。Kaplan-Meier分析和考克斯回归分析显示，PLR是一个显着的预测复发。结论：PLR，纤维蛋白原，PNI都是预测。特别地，PLR在预后能力方面上级其他基于炎症的评分。
Background: The significance of inflammation based scores including the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), and plasma fibrinogen remains unclear in medullary thyroid carcinoma (MTC). We aimed to compare the prognostic value of these scores.Methods: Seventy-eight patients newly diagnosed as MTC with operation in our institution from May 2009 to September 2016 were retrospectively evaluated. Receiver operating characteristic (ROC) curves and Kaplan-Meier analyses were calculated to compare the prognostic value of these scores.Results: Increased PLR was predictive of lymph node metastasis (AUC = 0.644, P = 0.022), capsule invasion (AUC = 0.666, P = 0.007), advanced tumor stages (AUC = 0.657, P = 0.011), and recurrence (AUC = 0.655, P = 0.049). Increased fibrinogen was predictive of lymph node metastasis (AUC = 0.669, P = 0.006) and capsule invasion (AUC = 0.631, P = 0.038). Reduced PNI was predictive of recurrence (AUC = 0.655, P = 0.049). Kaplan-Meier analyses and Cox regression analysis revealed that PLR was a significant predictor for recurrence.Conclusions: PLR, fibrinogen, and PNI are all predictive. Specially, PLR is superior to other inflammation based scores in terms of prognostic ability.