PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy.
PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy.
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PAMAM树状聚合物作为癌症治疗的有效药物和基因递送纳米系统。
DOI：
10.1016/j.apmt.2018.05.002
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发表时间：
2018-09
影响因子：
8.3
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Abedi-Gaballu F;Dehghan G;Ghaffari M;Yekta R;Abbaspour-Ravasjani S;Baradaran B;Dolatabadi JEN;Hamblin MR
肿瘤化疗药物释放系统是提高化疗药物疗效和减少毒副作用的重要手段。大多数化疗药物具有不加选择的细胞毒性，影响正常细胞和癌细胞。为了克服这些问题，越来越多地研究用于药物递送的新的更有效的纳米系统。聚酰胺-胺（PAMAM）树枝状聚合物是一种通用的和可重复的纳米载体类型的例子，其可以装载药物，并通过连接识别在癌细胞上过表达的受体的靶特异性配体进行修饰。具有高密度阳离子电荷的PAMAM树枝状聚合物显示与核酸（DNA、siRNA、miRNA等）的静电相互作用，产生可以保护核酸不被降解的树枝状复合物。树枝状聚合物是通过进行几个连续的“代”合成反应来制备的，因此它们的大小可以很容易地控制，并且它们具有良好的均匀性。树枝状聚合物特别适合于共递送应用（药物和/或基因的同时递送）。在目前的审查中，我们讨论了树枝状聚合物为基础的药物/基因的靶向输送和共输送系统主要用于癌症治疗。
Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have indiscriminate cytotoxicity that affects normal, as well as cancer cells. To overcome these problems, new more efficient nanosystems for drug delivery are increasingly being investigated. Polyamidoamine (PAMAM) dendrimers are an example of a versatile and reproducible type of nanocarrier that can be loaded with drugs, and modified by attaching target-specific ligands that recognize receptors that are over-expressed on cancer cells. PAMAM dendrimers with a high density of cationic charges display electrostatic interactions with nucleic acids (DNA, siRNA, miRNA, etc.), creating dendriplexes that can preserve the nucleic acids from degradation. Dendrimers are prepared by conducting several successive “generations” of synthetic reactions so their size can be easily controlled and they have good uniformity. Dendrimers are particularly well-suited to co-delivery applications (simultaneous delivery of drugs and/or genes). In the current review, we discuss dendrimer-based targeted delivery of drugs/genes and co-delivery systems mainly for cancer therapy.
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影响因子：
5.3
作者：
Ciuleanu, T.;Tsai, C. -M.;Thatcher, N.
通讯作者：
Thatcher, N.
影响因子：
3.5
作者：
Choi, Seok Ki;Verma, Manisha;Silpe, Justin;Moody, Ryan E.;Tang, Kenny;Hanson, Jeffrey J.;Baker, James R., Jr.
通讯作者：
Baker, James R., Jr.
影响因子：
5.8
作者：
Dolatabadi, Jafar Ezzati Nazhad;Hamishehkar, Hamed;Valizadeh, Hadi
通讯作者：
Valizadeh, Hadi
影响因子：
3.8
作者：
Eskandani, Morteza;Barar, Jaleh;Nazemiyeh, Hossein
通讯作者：
Nazemiyeh, Hossein
硫适体结合的 CD44 靶向递送系统用于体外和体内治疗乳腺癌。
影响因子：
4.5
作者：
Fan, Wei;Wang, Xiang;Lu, Qiping
通讯作者：
Lu, Qiping