Increases in Oxidized Low-Density Lipoprotein and Other Inflammatory and Adhesion Molecules With a Concomitant Decrease in High-Density Lipoprotein in the Individuals Exposed to Arsenic in Bangladesh
Increases in Oxidized Low-Density Lipoprotein and Other Inflammatory and Adhesion Molecules With a Concomitant Decrease in High-Density Lipoprotein in the Individuals Exposed to Arsenic in Bangladesh
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DOI：
10.1093/toxsci/kft130
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发表时间：
2013-09-01
影响因子：
3.8
通讯作者：
Hossain, Khaled
中科院分区：
文献类型：
--
作者：
Karim, Md Rezaul;Rahman, Mashiur;Hossain, Khaled
砷暴露水平的升高被认为与导致心血管疾病（CVD）的动脉粥样硬化有关。然而，砷诱导的动脉粥样硬化的生化事件尚未得到充分的证明。本研究的目的是调查孟加拉国砷暴露个体中动脉粥样硬化相关循环分子与砷暴露的关系。共招募了324名研究对象，其中218名来自孟加拉国砷流行地区，106名来自非砷流行地区。从研究受试者中采集饮用水、头发、指甲和血液样本进行分析。总胆固醇（TC），低密度脂蛋白（LDL），高密度脂蛋白（HDL）水平低于砷地方病受试者比非地方病受试者。氧化低密度脂蛋白（Ox-LDL），C-反应蛋白（CRP），细胞间粘附分子-1（ICAM-1），血管细胞粘附分子-1（VCAM-1）水平显着高于砷地方病患者比非地方病患者。所有这些循环分子显示出显着的相关性与砷暴露（水，头发，指甲砷浓度），所有这些关系是显着的相关协变量调整前后。在这项研究中检测的循环分子中，HDL、Ox-LDL和CRP显示出与砷暴露的剂量反应关系。Ox-LDL/ HDL比值随着砷浓度的增加而增加。此外，非高密度脂蛋白胆固醇和TC/ HDL比值显着相关的砷暴露前后调整相关的协变量。因此，所有观察到的相关性可能是砷中毒相关动脉粥样硬化导致CVD的主要特征。
Elevated exposure to arsenic has been suggested to be associated with atherosclerosis leading to cardiovascular disease (CVD). However, biochemical events underlying the arsenic-induced atherosclerosis have not yet been fully documented. The aim of this study was to investigate the associations of circulating molecules involved in atherosclerosis with arsenic exposure in the individuals exposed to arsenic in Bangladesh. A total of 324 study subjects, 218 from arsenic-endemic areas and 106 from nonendemic areas in Bangladesh, were recruited. Drinking water, hair, nail, and blood samples were collected from the study subjects for analysis. Total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were lower in arsenic-endemic subjects than those of nonendemic subjects. Oxidized LDL (Ox-LDL), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) levels were significantly higher in arsenic-endemic subjects than those in nonendemic subjects. All these circulating molecules showed significant correlations with arsenic exposure (water, hair, and nail arsenic concentrations), and all these relations were significant before and after adjusting for relevant covariates. Among the circulating molecules tested in this study, HDL, Ox-LDL, and CRP showed dose-response relationships with arsenic exposure. Ox-LDL/ HDL ratios were increased with the increasing concentrations of arsenic in the water, hair, and nails. Furthermore, non-HDL cholesterol and TC/ HDL ratios were significantly correlated with arsenic exposure before and after adjusting for relevant covariates. Thus, all the observed associations may be the major features of arsenic exposure-related atherosclerosis leading to CVD.