Haemato-pathological effect of dichlorvos on blood picture and liver cells of albino rats
Haemato-pathological effect of dichlorvos on blood picture and liver cells of albino rats
复制标题
敌敌畏对白化大鼠血象和肝细胞的血液病理影响
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
D. Onwuli
中科院分区：
文献类型：
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作者：
H. Brown;B. Kenanagha;D. Onwuli
为研究有机磷农药敌敌畏对大鼠血液学指标和肝脏病理的影响，将30只雄性大白鼠随机分为6组，每组6只，分别注射敌敌畏0、3.7、7.4、11.1、14.8和18.5 mg/kg(1ml/kg)。测量的血液学参数为红细胞、血红蛋白、红细胞压积、白细胞总数和血小板水平。同时对肝组织进行组织学检查。血液学指标显示，敌敌畏处理组大鼠红细胞、血红蛋白和红细胞压积均值显著降低(P<0.05)，白细胞总数和血小板计数显著升高(P<0.05)，且呈剂量依赖关系。观察到治疗组大鼠肝脏结构的变化为羽状外观、脂肪改变和小叶中心坏死。然而，在对照组大鼠的肝组织中没有观察到结构扭曲。敌敌畏具有剂量依赖性的靶标毒性。
关键词：肝脏、毒性、敌敌畏、农药、血液学。
The effect of intraperitonal exposure of dichlorvos an organophosphate (OP) pesticide, on haematology parameters and liver pathology of Wister rats was investigated. Thirty male albino rats grouped into six (6) of five rats each were injected with 0, 3.7, 7.4, 11.1, 14.8 and 18.5mg/kg of dichlorvos (DDVP) (1 ml/kg) respectively. The haematological parameters measured were red blood cells, haemoglobin; packed cell volume, total white blood cells count and platelet levels. Histological examination of liver tissue was investigated as well. The result of the haematological parameters of the dichlorvos treated rats showed a significant decrease (p<0.05) in the mean values of red blood cells, haemoglobin and packed cell volume and a significant increase (p<0.05) in the total white blood cell count and platelet count which was dose dependent. Changes observed in the liver architecture of the treated rat tissues were feathery looks, fatty changes and centrilobular necrosis. However there was no architectural distortion observed in the liver tissue of the control rats. Dichlorvos had dose dependent target toxicity.
Key words: Liver, toxicity, dichlorvos, pestiscides, haematology.