Anion gap and hypoalbuminemia
Anion gap and hypoalbuminemia
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DOI：
10.1097/00003246-199811000-00019
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发表时间：
1998-11-01
影响因子：
8.8
通讯作者：
Fencl, V
中科院分区：
文献类型：
--
作者：
Figge, J;Jabor, A;Fencl, V
目的：展示低蛋白血症如何降低阴离子间隙，这可以掩盖显著的间隙酸中毒；并推导出纠正因子。设计：观察性研究，背景：在一所大学附属医院的重症监护室。研究对象：9名正常人和152名危重病人(265项测量)。干预：无。测量和主要：结果：动脉血样分析pH值，二氧化碳分压，以及血浆电解质和蛋白质浓度。明显的低蛋白血症在危重患者中很常见：49%的患者血清白蛋白浓度为
Objectives: To show how hypoalbuminemia lowers the anion gap, which can mask a significant gap acidosis; and to derive a correction factor for it.Design: Observational study,Setting: Intensive care unit in a university-affiliated hospital.Subjects: Nine normal subjects and 152 critically ill patients (265 measurements).Interventions: None.Measurements and MainResults: Arterial blood samples analyzed for pH, PCO2, and concentrations of plasma electrolytes and proteins. Marked hypoalbuminemia was common among the critically ill patients: 49% of them had serum albumin concentration of