Usefulness of using laser-induced photoacoustic measurement and 3.0 Tesla MRI to assess knee cartilage damage: a comparison study.
Usefulness of using laser-induced photoacoustic measurement and 3.0 Tesla MRI to assess knee cartilage damage: a comparison study.
复制标题
使用激光诱导的光声测量和3.0 Tesla MRI评估膝盖软骨损伤的有用性：比较研究。
DOI：
10.1186/s13075-015-0899-4
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发表时间：
2015-12-30
影响因子：
4.9
通讯作者：
Mochida J
中科院分区：
文献类型：
--
作者：
Ukai T;Sato M;Ishihara M;Yokoyama M;Takagaki T;Mitani G;Tani Y;Yamashita T;Imai Y;Mochida J
T2标测是一种MRI方法，特别反映软骨中的胶原排列，扩散张量(DT)成像捕捉水分子的扩散。激光诱导光声测量(LIPA)不仅可以评估软骨层的厚度，还可以评估其粘弹性性质。通过使用LIPA和3.0Tesla MRI(T2标测和DT成像)评估软骨损伤，本研究调查了各种方法的有效性。采用国际软骨修复学会(ICRS)的分类标准，对29块手术中切除的骨软骨进行分类。同时，在与软骨损伤面积相匹配的部位进行LIPA。术前行MRI检查，测量T2和表观弥散系数。此外，还为每个ICRS分级准备了用于组织学评估的组织切片，并对各种方法的结果进行了比较。经DT成像，各分级间差异均有统计学意义(P <； 0.01)。经T2标测，除1级与2级外，其余各年级间均有显著差异(P <； 0.01)。LIPA组1级与3级(P <； 0.0 5)，1级与4级(P <； 0.0 1)，2级与4级(P <； 0.0 1)，3级与4级(P <； 0.0 5)有显著差异。在Mankin评分中，1级与3级(P <； 0.0 1)、1级与4级(P <； 0.0 1)、2级与4级(P <； 0.0 1)、3级与4级(P <； 0.0 1)有显著差异。在ICRS分级与DT成像、T2映射、LIPA和Mankin评分的所有组合中都观察到了相关性。组织学退变程度与DT成像、T2成像和ICRS分级之间存在相关性，但LIPA的相关性弱于MRI。在膝关节骨性关节炎的评估中，有时仅用MRI很难评估受损的软骨部位，我们认为联合使用LIPA和MRI是可取的。
T2 mapping is an MRI method particularly reflective of the collagen arrangement in the cartilage, and diffusion tensor (DT) imaging captures the diffusion of water molecules. Laser-induced photoacoustic measurement (LIPA) makes it possible to assess not only the thickness of the cartilage layer but also its viscoelastic properties. By assessing cartilage damage assessment using LIPA and 3.0 Tesla MRI (T2 mapping and DT imaging), this study investigates the usefulness of the various methods. The International Cartilage Repair Society (ICRS) classification was used to classify 29 bone cartilage pieces excised during surgical procedures. At the same time, LIPA was performed at sites matching the area of cartilage damage. MRI was performed preoperatively to measure the T2 and the apparent diffusion coefficient. In addition, tissue sections for histological assessment using the Mankin score were prepared for each ICRS grade, and the results with the various methods were compared. With DT imaging, significant differences were observed in all grades (P < 0.01). With T2 mapping, significant differences were observed in all grades except for grade 1 versus grade 2 (P < 0.01). With LIPA, significant differences were observed in ICRS grade 1 versus grade 3 (P < 0.05), grade 1 versus grade 4 (P < 0.01), grade 2 versus grade 4 (P < 0.01), and grade 3 versus grade 4 (P < 0.05). With the Mankin score, significant differences were observed in ICRS grade 1 versus grade 3 (P < 0.01), grade 1 versus grade 4 (P < 0.01), grade 2 versus grade 4 (P < 0.01), and grade 3 versus grade 4 (P < 0.01). Correlations were observed in all combinations of ICRS grade with DT imaging, T2 mapping, LIPA, and Mankin score. Correlations were observed between the degree of histological degeneration and DT imaging, T2 mapping, and ICRS grade, but LIPA had a weaker correlation than MRI. In the assessment of knee osteoarthritis, there are instances where it is difficult to assess the damaged cartilage site with MRI alone, and we believe that it is desirable to use a combination of LIPA and MRI.