Immunomodulatory effects of extracorporeal photochemotherapy in systemic sclerosis
Immunomodulatory effects of extracorporeal photochemotherapy in systemic sclerosis
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DOI：
10.1016/j.clim.2011.09.014
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发表时间：
2012-02-01
影响因子：
8.6
通讯作者：
Zeher, Margit
中科院分区：
文献类型：
--
作者：
Papp, Gabor;Horvath, Ildiko Fanny;Zeher, Margit
本研究的目的是评价体外光化学疗法（ECP）在系统性硬化症（SSc）中的临床和免疫调节作用。我们招募了16名弥漫性皮肤SSc患者，他们总共接受了12次ECP治疗。经ECP治疗后，皮肤厚度减少，关节活动度改善。内脏受累并未恶化。外周血Th 17细胞百分比和数量下降，Tr 1和Treg细胞值升高，Treg细胞的抑制能力增强。有趣的是，我们发现IL-17水平的降低与超声测量的皮肤厚度之间呈正相关。此外，在治疗期间，CCL 2和TGF-β的水平降低，而IL-1 Ra、IL-10和HGF的浓度升高。ECP治疗有助于恢复不成比例的自身免疫反应并减弱纤维化过程，从而减缓疾病进展。因此，ECP可以是针对SSc提出的新治疗模式的有用元素。(C)2011 Elsevier Inc. All rights reserved.
The aim of this study was to evaluate the clinical and immunomodulatory effects of extracorporeal photochemotherapy (ECP) in systemic sclerosis (SSc). We enrolled 16 patients with diffuse cutaneous SSc, who received 12 ECP treatments in total. After ECP treatments, the dermal thickness reduced and the mobility of joints improved. Internal organ involvement did not deteriorate. The percentages and numbers of peripheral Th17 cells decreased, the values of Tr1 and Treg cells increased, and the suppressor capacity of Treg cells improved. Interestingly, we found a positive correlation between the reduction of IL-17 levels and skin thickness measured by ultrasound. Moreover, levels of CCL2 and TGF-beta decreased, while the concentration of IL-1Ra, IL-10 and HGF elevated during the therapy. ECP treatments contribute to the restoration of disproportional autoimmune responses and attenuate fibrotic processes, thus decelerate the disease progression. Accordingly, ECP can be a useful element of novel treatment modalities proposed for SSc. (C) 2011 Elsevier Inc. All rights reserved.