ArchAlign: coordinate-free chromatin alignment reveals novel architectures.
ArchAlign: coordinate-free chromatin alignment reveals novel architectures.
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DOI:
10.1186/gb-2010-11-12-r126
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发表时间:
2010
期刊:
影响因子:
12.3
通讯作者:
Buck MJ
中科院分区:
文献类型:
--
作者:
Lai WK;Buck MJ
To facilitate identification and characterization of genomic functional elements, we have developed a chromatin architecture alignment algorithm (ArchAlign). ArchAlign identifies shared chromatin structural patterns from high-resolution chromatin structural datasets derived from next-generation sequencing or tiled microarray approaches for user defined regions of interest. We validated ArchAlign using well characterized functional elements, and used it to explore the chromatin structural architecture at CTCF binding sites in the human genome. ArchAlign is freely available at http://www.acsu.buffalo.edu/~mjbuck/ArchAlign.html.
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