Visual stimulus-driven functional organization of macaque prefrontal cortex
Visual stimulus-driven functional organization of macaque prefrontal cortex
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DOI：
10.1016/j.neuroimage.2018.11.060
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发表时间：
2019-03-01
期刊：
影响因子：
5.7
通讯作者：
Conway, Bevil R.
中科院分区：
文献类型：
--
作者：
Haile, Theodros M.;Bohon, Kaitlin S.;Conway, Bevil R.
前额叶皮层（PFC）的主要分支可以在多大程度上进行功能划分尚不清楚。在处理这个问题时，通常假设组织是任务依赖的。在这里，我们使用功能磁共振成像显示PFC可以以任务独立的方式做出反应，我们利用这些反应来揭示刺激驱动的功能组织。结果是通过绘制4只被动注视猕猴对面孔、身体、场景、差异、颜色和怪癖反应的相对位置而产生的。结果控制了功能结构的个体差异，并首次解释了整个PFC系统的视觉刺激驱动的功能组织。反应集中在腹侧预海马区的背外侧PFC (DLPFC)；在腹侧PFC （VLPFC）中，延伸到眼眶PFC。面部斑块是VLPFC的焦点，其特征是对非面部刺激的反应明显缺乏，而不是对面部的特别强烈的反应。颜色偏倚的区域接近但与面部斑块不同。一个场景偏置区域与不同的对比度一致定位，并重叠差异偏置区域以定义DLPFC焦点。所有视觉反应区域均表现出周边视野偏置。这些结果揭示了一个组织方案，可能限制了不同视觉模式的信息流进入PFC。
The extent to which the major subdivisions of prefrontal cortex (PFC) can be functionally partitioned is unclear. In approaching the question, it is often assumed that the organization is task dependent. Here we use fMRI to show that PFC can respond in a task-independent way, and we leverage these responses to uncover a stimulus-driven functional organization. The results were generated by mapping the relative location of responses to faces, bodies, scenes, disparity, color, and eccentricity in four passively fixating macaques. The results control for individual differences in functional architecture and provide the first account of a systematic visual stimulus-driven functional organization across PFC. Responses were focused in dorsolateral PFC (DLPFC), in the ventral prearcuate region; and in ventrolateral PFC (VLPFC), extending into orbital PFC. Face patches were in the VLPFC focus and were characterized by a striking lack of response to non-face stimuli rather than an especially strong response to faces. Color-biased regions were near but distinct from face patches. One scene-biased region was consistently localized with different contrasts and overlapped the disparity-biased region to define the DLPFC focus. All visually responsive regions showed a peripheral visual-field bias. These results uncover an organizational scheme that presumably constrains the flow of information about different visual modalities into PFC.