The effect of chloroquine treatment on the infectivity of Plasmodium chabaudi gametocytes
The effect of chloroquine treatment on the infectivity of Plasmodium chabaudi gametocytes
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DOI：
10.1016/s0020-7519(98)00230-6
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发表时间：
1999-04-01
影响因子：
4
通讯作者：
Read, AF
中科院分区：
文献类型：
--
作者：
Buckling, AGJ;Read, AF
据报告，抗疟药氯喹可增加血液阶段疟疾寄生虫（配子体）的感染性，这些疟原虫能够感染蚊子媒介。这种效果在短期内（治疗后12小时）已得到令人信服的证明，尽管一些作者建议在治疗后一周或更长时间内增强感染性。我们进行了实验，以调查氯喹的长期感染性的配子体的啮齿类疟疾寄生虫，夏氏疟原虫，斯氏按蚊的影响。氯喹治疗感染的配子细胞比未治疗的感染在治疗后6天和7天显著更具感染性，尽管在第8天和第9天没有。然而，这种效应很可能是由于免疫活性导致未经治疗的感染的感染性降低，而免疫活性在氯喹治疗的感染中并不那么明显。配子细胞血症（配子细胞/r. b.c.）与感染力呈强正相关和线性关系。繁殖力不受无性寄生虫病，无性密度或贫血的影响。氯喹对配子体感染性的影响的吝啬的解释进行了讨论。(C)1999年澳大利亚寄生虫学会由Elsevier Science Ltd.出版，版权所有。
The antimalarial drug chloroquine has been reported to increase the infectivity of the forms of blood-stage malaria parasites (gametocytes) that are capable of infecting mosquito vectors. This effect has been demonstrated convincingly in the short term (12 h post treatment), although several authors have suggested infectivity enhancement a week or more after treatment. We carried out experiments to investigate the effects of chloroquine on the longer-term infectivity of gametocytes of the rodent malaria parasite, Plasmodium chabaudi, to Anopheles stephensi mosquitoes. Gametocytes of chloroquine-treated infections were significantly more infectious than untreated infections 6 and 7 days post-treatment, although not on days 8 and 9. However, this effect was most likely the result of a reduction in infectivity in untreated infections, caused by immune activity which was not so pronounced in chloroquine-treated infections. Gametocytaemia (gametocytes per r.b.c.) showed a strong positive and linear relationship with infectivity. Infectivity was not influenced by either asexual parasitaemia, asexual density or anaemia. Parsimonious interpretations of the effect of chloroquine on gametocyte infectivity are discussed. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.