Osteoclasts, mononuclear phagocytes, and physiological bone resorption.
Osteoclasts, mononuclear phagocytes, and physiological bone resorption.
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破骨细胞、单核吞噬细胞和生理性骨吸收。
DOI：
10.1007/bf02555171
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发表时间：
1986
影响因子：
4.2
通讯作者：
Shapiro,IM
中科院分区：
文献类型：
--
作者：
Minkin,C;Shapiro,IM
结论本文中表达的担忧以及其他人在最近的综述中提到的担忧，强调了文献中关于破骨细胞在骨吸收中的作用的混乱，因为破骨细胞与单核吞噬细胞不同。如果采纳以下建议，这种混乱是可以解决的。首先，术语“吸收”或“骨吸收”应该被保留来描述以破骨细胞为主要功能细胞类型的骨去除过程。其次，术语破骨细胞应该被用来定义骨吸收细胞，其特征是前面提出的标准。第三，在提供明确的证据之前，不能假设单核巨噬细胞系列的细胞，如外周血单核细胞或诱导的腹膜巨噬细胞，是破骨细胞的前体。
ConclusionsThe concerns expressed here, as well as those noted by others in recent reviews, underscore the confusion that has entered the literature regarding the role of osteoclasts, as distinct from that of mononuclear phagocytes, in bone resorption. This confusion could be resolved if the following suggestions are adopted. First, the term “resorption” or “bone resorption” should be reserved for describing a process of bone removal in which osteoclasts are the primary function cell type. Second, the term osteoclast should be used to define a bone-resorbing cell characterized by the criteria presented earlier. Third, until unambiguous evidence is provided, it must not be assumed that cells of the mononuclear phagocyte series, such as peripheral blood monocytes or elicited peritoneal macrophages, are osteoclast precursors.