Can we apply the national cholesterol education program adult treatment panel definition of the metabolic syndrome to Asians?
Can we apply the national cholesterol education program adult treatment panel definition of the metabolic syndrome to Asians?
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DOI：
10.2337/diacare.27.5.1182
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发表时间：
2004-05-01
期刊：
影响因子：
16.2
通讯作者：
Tai, ES
中科院分区：
文献类型：
--
作者：
Tan, CE;Ma, S;Tai, ES
目的-有限的信息是关于亚洲人的代谢综合征。此外，用腰围来定义中心性肥胖可能不适合亚洲人。本研究的目的是确定诊断亚洲人中心性肥胖的最佳腰围，并估计亚洲人群中代谢综合征的患病率。研究设计和方法-我们使用的数据来自1998年新加坡国家健康调查，一项横断面调查，涉及4，723名年龄在18-61岁的中国人、马来人和亚洲-印度人。接受者操作特征分析表明，女性腰围>80 cm和男性腰围>90 cm是该人群中更合适的中心性肥胖定义。然后使用国家胆固醇教育计划成人治疗小组III确定代谢综合征的患病率（NCEP ATP III）标准有和没有修改的腰围标准。结果-在亚洲人中，腰围减小使代谢综合征的粗患病率从12.2%增加到17.9%。使用改良的亚洲标准，代谢综合征的患病率从18-30岁的2.9%增加到60-69岁的31.0%。在男性（男性患病率20.9%，女性患病率15.5%，P < 0.001）和亚裔印度人（亚裔印度人患病率28.8%，马来人患病率24.2%，华人患病率14.8%，P < 0.001）中更为常见。在较低的腰围截止值下，代谢综合征的患病率与西方人群相当。亚洲各地的人口之间可能存在种族差异。
OBJECTIVE - Limited information is available about the metabolic syndrome in Asians. Furthermore, the definition of central obesity using waist circumference may not be appropriate for Asians. The objectives of this study were to determine the optimal waist circumference for diagnosing central obesity in Asians and to estimate the prevalence Of the metabolic syndrome in an Asian population.RESEARCH DESIGN AND METHODS - We used data from the 1998 Singapore National Health Survey, a cross-sectional survey involving 4,723 men and women of Chinese, Malay, and Asian-Indian ethnicity aged 18-61) years. Receiver operating characteristic analysis suggested that waist circumference >80 cm in women and n>90 cm in men was a more appropriate definition of central obesity in this population, The prevalence of the metabolic syndrome was then determined using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria With and without the modified waist circumference criteria.RESULTS - In Asians, decreasing waist circumference increased the crude prevalence of the metabolic syndrome from 12.2 to 17.9%. Using the modified Asian criteria, the prevalence of the metabolic syndrome increased from 2.9% in those aged 18-30 years to 31.0% in those aged 60-69 years. It was more common in men (prevalence 20.9% in men versus 15.5% in women P < 0.001) and Asian Indians (prevalence 28.8% in Asian-Indians, 24.2% in Malays, and 14.8% in Chinese; P < 0.001).CONCLUSIONS - NCEP ATP III criteria, applied to an Asian population, will underestimate the population at risk. With a lower waist circumference cutoff, the prevalence of the metabolic syndrome is comparable to that in Western populations. Ethnic differences are likely to exist between populations across Asia.