Quantitative analysis of serum levels of trace elements in patients with oral submucous fibrosis and oral squamous cell carcinoma: A randomized cross-sectional study.
Quantitative analysis of serum levels of trace elements in patients with oral submucous fibrosis and oral squamous cell carcinoma: A randomized cross-sectional study.
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DOI：
10.4103/0973-029x.131902
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Chitra, S
中科院分区：
文献类型：
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作者：
Hosthor, Sreelatha S;Mahesh, Pushpalatha;Chitra, S
背景与目的：代谢紊乱、口腔癌前病变和口腔癌都伴随着某些体液特别是血清或血浆中铜、铁、锌、镁等一种或多种微量元素浓度的变化，这不仅有助于早期诊断和治疗，而且有助于预后。本研究的目的是评估口腔粘膜下纤维化 (OSF) 和口腔鳞状细胞癌 (OSCC) 患者血清中循环微量元素（铜、铁、镁、锌和钙）的水平，分析这些参数的变化并确定疾病发生和进展的最佳预测因子及其与槟榔和槟榔咀嚼习惯的关系。 材料和方法：微量元素（铜、使用电子吸收比色法估算铁、镁、锌和钙。将这些水平与对照进行比较，并使用方差分析和事后TUKEY检验进行统计评估。结果：数据分析显示，随着咀嚼槟榔习惯持续时间的增加，血清铜水平从癌前到癌症逐渐增加。然而，两组的血清铁、镁、锌水平均显着下降。由于疾病后期的骨吸收，癌症组的血清钙水平升高，而 OSF 患者的血清钙水平接近正常。在所有微量元素中，铜是两种病变发生的最佳预测因子。结论：本研究表明上述微量元素可能与OSF和OSCC的发病和进展有关。槟榔和槟榔的咀嚼习惯通常与这两种疾病状态有关，并且可能在改变这些微量元素的血清水平方面发挥作用。因此，共同努力将有助于早期发现、管理和监测治疗效果。
BACKGROUND AND OBJECTIVES: Metabolic disorders, oral precancerous conditions and oral cancer are accompanied by alterations in the concentration of one or more trace elements like copper, iron, zinc, magnesium etc., in some body fluids, especially blood serum or plasma, which can help not only in the early diagnosis and treatment but also in prognosis. The objective of the study is to evaluate the levels of circulating trace elements (copper, iron, magnesium, zinc and calcium) in serum of patients with Oral Submucous Fibrosis (OSF) and Oral Squamous Cell Carcinoma (OSCC), to analyze the alteration and identify the best predictors amongst these parameters for disease occurrence and progression and their association with areca nut and betel quid chewing habits.MATERIALS AND METHOD: Serum levels of trace elements (copper, iron, magnesium, zinc and calcium) were estimated using electronic absorption colorimetric method. These levels were compared with controls and statistically evaluated using ANOVA and POST-HOC TUKEY tests.RESULTS: The data analysis revealed that serum copper levels increased gradually from precancer to cancer, as the duration of betel quid chewing habit increased. However, serum iron, magnesium, zinc levels were decreased significantly in both the groups. Serum calcium levels were increased in the cancer group owing to bone resorption in the later stages of the disease, whereas it was close to normal in OSF patients. Among all the trace elements, the best predictor for occurrence of both the lesions was copper.CONCLUSION: The present study shows that the above trace elements may be associated with the pathogenesis and progression of OSF and OSCC. Betel quid and areca nut chewing habits are frequently associated with both disease states and may play a role in altering the serum levels of these trace elements. Concerted efforts would, therefore, help in early detection, management and monitoring the efficacy of treatment.