UNEVEN DISTRIBUTION OF MATERNAL AND FETAL PLACENTAL BLOOD FLOW AS DEMONSTRATED USING MACROAGGREGATES AND ITS RESPONSE TO HYPOXIA
UNEVEN DISTRIBUTION OF MATERNAL AND FETAL PLACENTAL BLOOD FLOW AS DEMONSTRATED USING MACROAGGREGATES AND ITS RESPONSE TO HYPOXIA
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DOI：
10.1172/jci105693
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发表时间：
1967-01-01
影响因子：
15.9
通讯作者：
FROSTER, RE
中科院分区：
文献类型：
--
作者：
POWER, GG;LONGO, LD;FROSTER, RE
本文描述了一种用放射性标记的白蛋白大聚集体研究绵羊和狗的母体和胎儿胎盘血管血流分布的技术。当母动物呼吸室内空气时，母胎盘血流在子叶间和子叶内的分布是不均匀的。子叶间和子叶内胎儿血流分布也不均匀。母体与胎儿胎盘血流的关系也明显不均匀（相关系数，τ = 0.066）。动物呼吸10-12% o2缺氧后，母体、胎儿及母体/胎儿胎盘血流分布更加均匀。母胎流量相关系数较高（τ = 0.53，P< 0.01）。当母动物呼吸室内空气时，在脐带动脉主干结扎后，母体、胎儿和母体/胎儿血流在剩余的三分之二到四分之三的胎盘中的分布变得更加均匀。母胎流量的相关系数较高（τ = 0.35，P< 0.01）。在血流分布不均匀的正常情况下，似乎有相当一部分胎盘没有获得最佳数量的血流来促进有效的o2交换。如果不考虑母体/胎儿流量不均匀的影响，将导致高估母胎平均氧张力梯度，从而低估胎盘的氧扩散能力。在母体缺氧或胎儿胎盘循环受损的情况下，母体、胎儿和母体/胎儿的血流分布变得更加均匀，从而提高了胎盘o2交换的效率。图片
A technique is described for studying the distribution of blood flow to the maternal and fetal placental vessels in sheep and dogs with radioactive labeled macroaggregates of albumin.When the maternal animal breathed room air the distribution of maternal placental blood flow was uneven among the cotyledons as well as within a given cotyledon. Fetal blood flow was also distributed nonuniformly among and within the cotyledons. The relation of maternal to fetal placental blood flow was also markedly uneven (coefficient of correlation, τ = 0.066). After the animal was made hypoxic by breathing 10-12% O2the distribution of maternal, fetal, and maternal/fetal placental flows became more uniform. The coefficient of correlation of maternal to fetal flow was high (τ = 0.53,P< 0.01). While the maternal animal breathed room air, after ligation of a major branch of the umbilical artery the distribution of maternal, fetal, and maternal/fetal flows in the remaining two-thirds to three-fourths of the placenta became more uniform. The correlation coefficient for maternal to fetal flow was high (τ = 0.35,P< 0.01).It appears that under normal circumstances with uneven distribution of blood flows there is a considerable portion of the placenta that does not receive blood flow in optimum quantities to promote efficient O2exchange. Failure to consider the influence of nonuniform maternal flow/fetal flow will result in overestimation of mean maternal-fetal oxygen tension gradients, and thus underestimation of the placental diffusing capacity for oxygen.In response to maternal hypoxia or compromise of the fetal placental circulation the distribution of maternal, fetal, and maternal/fetal flows becomes more uniform, thereby increasing the efficiency of placental O2exchange.Images