In Vitro Activities of 11 Antimicrobial Agents against Macrolide-Resistant Mycoplasma pneumoniae Isolates from Pediatric Patients: Results from a Multicenter Surveillance Study
In Vitro Activities of 11 Antimicrobial Agents against Macrolide-Resistant Mycoplasma pneumoniae Isolates from Pediatric Patients: Results from a Multicenter Surveillance Study
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DOI：
10.7883/yoken.65.535
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发表时间：
2012-11-01
影响因子：
2.2
通讯作者：
Ouchi, Kazunobu
中科院分区：
文献类型：
--
作者：
Akaike, Hiroto;Miyashita, Naoyuki;Ouchi, Kazunobu
对大环内酯类抗生素耐药的肺炎支原体正在几个国家出现，主要在儿童中观察到。据我们所知，我们进行了第一次大环内酯类耐药肺炎支原体的多中心前瞻性流行病学研究，以调查大环内酯类耐药肺炎支原体对抗菌药物敏感性的地区差异。研究了来自日本5个不同地区的11种抗菌药对大环内酯类耐药肺炎支原体的体外抗菌活性。在190株肺炎支原体中，124株(65.2%)对大环内酯类抗生素耐药，且在23S rRNA的V区存在A2063G转换。这些菌株对红霉素、克拉霉素和阿奇霉素表现出较高的耐药性，最低抑菌浓度(MICs)为16mU g/ml，而喹诺酮类药物如加瑞诺沙星、莫西沙星、妥舒沙星和左氧氟沙星则表现出较强的抗支原体活性。在日本的5个地区之间，没有观察到MICs的地区差异。
Macrolide-resistant Mycoplasma pneumoniae is emerging in several countries, and it is mainly observed in children. To our knowledge, we conducted the first multicenter prospective epidemiological study of macrolide-resistant M. pneumoniae in order to investigate regional differences in the susceptibility of macrolide-resistant M. pneumoniae to antibacterial agents. The in vitro activities of 11 antimicrobial agents against macrolide-resistant M. pneumoniae isolates from 5 different areas of Japan were investigated. Among 190 M. pneumoniae isolates from pediatric patients, 124 (65.2%) isolates showed macrolide resistance and possessed an A2063G transition in domain V of the 23S rRNA. These isolates showed high resistance to erythromycin, clarithromycin, and azithromycin with minimum inhibitory concentrations (MICs) >= 16 mu g/ml. Conversely, quinolones such as garenoxacin, moxifloxacin, tosufloxacin, and levofloxacin exhibited potent antimycoplasmal activity. No regional differences were observed with respect to the MICs among the 5 areas in Japan.