Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway
Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway
复制标题
萝卜硫素通过抑制音刺猬通路抑制胃癌干细胞
DOI：
10.1080/09637486.2018.1545012
复制
发表时间：
2019-07-04
影响因子：
3.9
通讯作者：
Zhong, Caiyun
中科院分区：
文献类型：
--
作者：
Ge, Miaomiao;Zhang, Lu;Zhong, Caiyun
萝卜硫素（SFN）是从西兰花/西兰花芽中提取的主要成分。它已被证明具有抗癌活性。胃癌是世界范围内常见的恶性肿瘤。本研究旨在通过Hh信号通路探讨SFN对胃癌的抑制作用。结果发现，SFN治疗后，肿瘤球形成和胃癌干细胞（CSCs）标志物的表达水平显着降低。SFN还通过抑制胃CSC的增殖和诱导凋亡发挥抑制作用。有趣的是，SFN抑制了Sonic Hh的激活，这是维持胃CSC干性的关键途径。上调Sonic Hh通路可减弱SFN对胃CSC的抑制作用。总之，这些数据表明，SFN可能是一种有效的天然化合物，通过抑制Sonic Hh途径靶向胃CSC，这可能是一种有前途的胃癌干预剂。
Sulforaphane (SFN) is the major component extracted from broccoli/broccoli sprouts. It has been shown to possess anti-cancer activity. Gastric cancer is common cancer worldwide. The objective of this work was to evaluate the inhibitory effect of SFN on gastric cancer by Sonic hedgehog (Hh) Pathway. The results found that tumorsphere formation and the expression levels of gastric cancer stem cells (CSCs) markers were significantly decreased after SFN treatment. SFN also exerted inhibitory effects by suppressing proliferation and inducing apoptosis in gastric CSCs. Intriguingly, SFN inhibited the activation of Sonic Hh, a key pathway in maintaining the stemness of gastric CSCs. Upregulation of Sonic Hh pathway diminished the inhibitory effects of SFN on gastric CSCs. Collectively, these data revealed that SFN could be a potent natural compound targeting gastric CSCs via suppression of Sonic Hh pathway, which might be an promising agent for gastric cancer intervention.