Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery
Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery
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DOI：
10.1007/s10544-009-9308-6
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发表时间：
2009-08-01
影响因子：
2.8
通讯作者：
Olbricht, William L.
中科院分区：
文献类型：
--
作者：
Foley, Conor P.;Nishimura, Nozomi;Olbricht, William L.
对流增强给药（CED）可以改善药物直接进入大脑的空间分布。在CED中，药物通过插入脑实质的针或导管局部输注到组织中。输注材料的输送由对流主导，与扩散介导的递送相比，对流增强了药物渗透到组织中。我们已经制造并表征了用于慢性对流增强递送方案的可植入微流体装置。该装置由柔性聚对二甲苯-C微流体通道组成，在插入组织期间由可生物降解的聚（DL-丙交酯-共-乙交酯）支架支撑。该支架被设计成能够穿透组织，然后随着时间的推移被侵蚀，仅留下植入组织中的柔性通道。该装置能够在急性实验中可重复地将液体注射到神经组织中，最终输注液分布非常接近理想点源的输送。该系统显示出作为慢性CED协议的工具的希望。
Convection enhanced delivery (CED) can improve the spatial distribution of drugs delivered directly to the brain. In CED, drugs are infused locally into tissue through a needle or catheter inserted into brain parenchyma. Transport of the infused material is dominated by convection, which enhances drug penetration into tissue compared with diffusion mediated delivery. We have fabricated and characterized an implantable microfluidic device for chronic convection enhanced delivery protocols. The device consists of a flexible parylene-C microfluidic channel that is supported during its insertion into tissue by a biodegradable poly(DL-lactide-co-glycolide) scaffold. The scaffold is designed to enable tissue penetration and then erode over time, leaving only the flexible channel implanted in the tissue. The device was able to reproducibly inject fluid into neural tissue in acute experiments with final infusate distributions that closely approximate delivery from an ideal point source. This system shows promise as a tool for chronic CED protocols.