Multifunctional membrane vesicles in Pseudomonas aeruginosa
Multifunctional membrane vesicles in Pseudomonas aeruginosa
复制标题
铜绿假单胞菌的多功能膜囊泡
DOI：
10.1111/j.1462-2920.2011.02632.x
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发表时间：
2012
影响因子：
5.1
通讯作者：
Nobuhiko Nomura
中科院分区：
文献类型：
--
作者：
Yosuke Tashiro;Hiroo Uchiyama;Nobuhiko Nomura
革兰氏阴性菌将称为膜囊泡（MV）的小颗粒分泌到细胞外环境中。虽然MVs在将病原菌的毒素传递到真核细胞中具有重要作用，但这些囊泡也在各种环境条件下发挥生存所必需的生态作用。铜绿假单胞菌生活在土壤，海洋，植物，动物和人类环境中，已成为研究这些小胞外颗粒的模式生物。铜绿假单胞菌MVs具有多种成分和结构独特的化学物质。这些特性使MV发挥其多功能的生物学作用，包括微生物相互作用，生物膜结构的维持和宿主感染。本文综述了铜绿假单胞菌MVs的生化和理化特性。 这些研究将有助于我们了解MV的生物学作用，不仅在致病性，而且在微生物生态学。此外，MV生产的机制，目前所了解的，进行了讨论。
Gram‐negative bacteria secrete small particles called membrane vesicles (MVs) into the extracellular milieu. While MVs have important roles in delivering toxins from pathogenic bacteria to eukaryotic cells, these vesicles also play ecological roles necessary for survival in various environmental conditions.Pseudomonas aeruginosa, which lives in soil, ocean, plant, animal and human environments, has become a model organism for studying these small extracellular particles. Such studies have increased our understanding of the function and biogenesis of bacterial MVs.Pseudomonas aeruginosaMVs possess versatile components and chemical substances with unique structures. These characteristics allow MVs to play their multifunctional biological roles, including microbial interaction, maintenance of biofilm structure and host infection. This review summarizes the comprehensive biochemical and physiochemical properties of MVs derived fromP. aeruginosa. These studies will help us understand their biological roles of MVs not only in pathogenicity but also in microbial ecology. Also, the mechanisms of MV production, as currently understood, are discussed.