Sensitivity of multi-shell NODDI to multiple sclerosis white matter changes: a pilot study.
Sensitivity of multi-shell NODDI to multiple sclerosis white matter changes: a pilot study.
复制标题
多壳 NODDI 对多发性硬化症白质变化的敏感性：一项试点研究。
作者：
T. Schneider;W. Brownlee;H. Zhang;O. Ciccarelli;David H. Miller;C. Wheeler
弥散张量成像 (DTI) 对多发性硬化症 (MS) 中的白质 (WM) 损伤敏感，不仅在局灶性病变中，而且在正常表现的 WM (NAWM) 中也如此。然而，DTI 指数也会受到 WM 自然空间变化的影响，如交叉和分散的白质纤维所示。神经突定向色散和密度成像 (NODDI) 是一种先进的扩散加权成像技术，可提供不同的纤维密度和色散指数。我们对五名多发性硬化症患者和五名对照者进行了病变组织的 NODDI 和 NAWM，并将该技术与传统的 DTI 进行了比较。 DTI 和 NODDI 均发现 NAWM 和病变中的组织损伤。 NODDI 能够检测到额外的变化，并且在 MS-NAWM 微观结构中提供更好的对比度，因为它比 DTI 更好地区分取向色散和纤维密度。我们表明，NODDI 在 MS 患者中是可行的，并且与 DTI 参数相比，它提供了更高的灵敏度，并且可能对神经突方向等微观结构特征具有更高的特异性。
Diffusion tensor imaging (DTI) is sensitive to white matter (WM) damage in multiple sclerosis (MS), not only in focal lesions but also in the normal-appearing WM (NAWM). However, DTI indices can also be affected by natural spatial variation in WM, as seen in crossing and dispersing white matter fibers. Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion-weighted imaging technique that provides distinct indices of fiber density and dispersion. We performed NODDI of lesion tissue and NAWM in five MS patients and five controls, comparing the technique with traditional DTI. Both DTI and NODDI identified tissue damage in NAWM and in lesions. NODDI was able to detect additional changes and it provided better contrast in MS-NAWM microstructure, because it distinguished orientation dispersion and fiber density better than DTI. We showed that NODDI is viable in MS patients and that it offers, compared with DTI parameters, improved sensitivity and possibly greater specificity to microstructure features such as neurite orientation.