Regulation of NF-κB by ubiquitination.
Regulation of NF-κB by ubiquitination.
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DOI：
10.1016/j.coi.2012.12.005
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发表时间：
2013-02
影响因子：
7
通讯作者：
Chen ZJ
中科院分区：
文献类型：
--
作者：
Chen J;Chen ZJ
核因子κ增强子结合蛋白（NF-κB）家族的转录因子调节参与多种细胞过程（包括炎症、免疫和细胞存活）的大量基因的表达。NF-κB的活化需要泛素化，泛素化是一种高度保守和多功能的修饰，可以通过蛋白酶体依赖性和非依赖性机制调节细胞信号传导。近年来的研究为NF-κB的泛素化调控机制提供了新的视角，包括泛素的多个连接、泛素结合的重要作用以及未锚定的多聚泛素链的功能。本文就泛素化在NF-κB调控中的作用及其机制进行综述。
The nuclear factor κ enhancer binding protein (NF-κB) family of transcription factors regulates the expression of a large array of genes involved in diverse cellular processes including inflammation, immunity and cell survival. Activation of NF-κB requires ubiquitination, a highly conserved and versatile modification that can regulate cell signaling through both proteasome dependent and independent mechanisms. Studies in the past few years have provided new insights into the mechanisms underlying regulation of NF-κB by ubiquitination, including the involvement of multiple linkages of ubiquitin, the essential role of ubiquitin binding, and the function of unanchored polyubiquitin chains. In this review, we will focus on recent advances in understanding the role of ubiquitination in NF-κB regulation in various pathways.
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