Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia - A longitudinal magnetic resonance imaging study
Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia - A longitudinal magnetic resonance imaging study
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DOI：
10.1001/archpsyc.60.8.766
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发表时间：
2003-08-01
影响因子：
--
通讯作者：
McCarley, RW
中科院分区：
文献类型：
--
作者：
Kasai, K;Shenton, ME;McCarley, RW
背景：赫施尔回和颞平面在听觉感知和语言处理中起着至关重要的作用。我们之前使用磁共振成像（MRI）进行的研究表明，首发精神分裂症患者的赫施尔回和左侧颞平面的双侧灰质体积较小，但首发情感性精神病患者则不然。我们试图确定首发精神分裂症患者以及首发情感性精神病患者的赫施尔回和颞平面的解剖学上定义的 MRI 灰质体积是否存在进行性减少。方法：在一家私立精神病医院，我们进行了一项前瞻性高空间分辨率 MRI 研究，包括 28 名患者首次住院时的初始扫描（13 名患有精神分裂症，15 名患有精神分裂症）。情感性精神病（其中 13 人患有躁狂精神病）和 22 名健康对照受试者。随访扫描平均在初次扫描后 1.5 年进行。结果：与首发情感性精神病患者或对照受试者相比，首发精神分裂症患者的左侧赫什尔回 (6.9%) 和左侧颞平面 (7.2%) 的灰质体积随着时间的推移显着减少。结论：这些发现表明，赫什尔回和颞平面的灰质体积呈左偏进行性减少。首发精神分裂症患者的颞叶灰质与首发情感性精神病患者和对照受试者相比。精神分裂症而非情感性精神病似乎以左颞上回新皮质灰质体积损失的发病后进展为特征，因此可能不是发育固定的。
Background: The Heschl gyrus and planum temporale have crucial roles in auditory perception and language processing. Our previous investigation using magnetic resonance imaging (MRI) indicated smaller gray matter volumes bilaterally in the Heschl gyrus and in left planum temporale in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis. We sought to determine whether there are progressives decreases in anatomically defined MRI gray matter volumes of the Heschl gyrus and planum temporale in patients with first-episode schizophrenia and also in patients with first-episode affective psychosis.Methods: At a private psychiatric hospital, we conducted a prospective high spatial resolution MRI study that included initial scans of 28 patients at their first hospitalization (13 with schizophrenia and 15 with affective psychosis, 13 of whom had a manic psychosis) and 22 healthy control subjects. Follow-up scans occurred, on average, 1.5 years after the initial scan.Results: Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left Heschl gyrus (6.9%) and left planum temporale (7.2%) compared with patients with first-episode affective psychosis or control subjects.Conclusions: These findings demonstrate a left-biased progressive volume reduction in the Heschl gyrus and planum temporale gray matter in patients with first-episode schizophrenia in contrast to patients with first-episode affective psychosis and control subjects. Schizophrenia but not affective psychosis seems to be characterized by a postonset progression of neocortical gray matter volume loss in the left superior temporal gyrus and thus may not be developmentally fixed.