Immunolocalization of cytokines and growth factors in subacromial bursa of rotator cuff tear patients.
Immunolocalization of cytokines and growth factors in subacromial bursa of rotator cuff tear patients.
复制标题
肩袖撕裂患者肩峰下囊中细胞因子和生长因子的免疫定位。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
K. Mizuno
中科院分区：
文献类型：
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作者：
H. Sakai;K. Fujita;Y. Sakai;K. Mizuno
肩峰下囊中的炎症引起患有肩袖撕裂的患者的疼痛，这种持久的炎症导致肩峰下囊的纤维化和增厚。炎性细胞因子和机械应力以及肩峰下间隙的撞击都可能诱发和加重这种炎症。然而，对这种炎症的机制知之甚少。在这项研究中，我们使用免疫组织化学染色，以证明白细胞介素-1 β（IL-1 β），肿瘤坏死因子α（TNF-α），转化生长因子β（TGF-β），和碱性成纤维细胞生长因子（bFGF）的表达肩峰下囊从患者患有肩袖撕裂。另一方面，这些炎性细胞因子和生长因子的表达很少检测到，只有在一个小的程度上在肩关节前不稳定的患者没有严重的肩关节疼痛和撞击肩峰下空间。提示这些炎症细胞因子和生长因子在肩峰下囊的炎症反应中起重要作用。控制这些细胞因子和生长因子的表达对于治疗肩袖撕裂引起的肩痛患者可能是重要的。
Inflammation in the subacromial bursa causes pain in patients suffering from rotator cuff tear, with this long-lasting inflammation leading to fibrosis and thickening of the subacromial bursa. Both inflammatory cytokines and mechanical stress, and impingement in the subacromial space, might induce and worsen this inflammation. However, little is known of the mechanism of this inflammation. In this study, we used immunohistological staining to demonstrate the expression of Interleukin-1 beta (IL-1 beta), Tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), and basic fibroblast growth factor (bFGF) in subacromial bursa derived from the patients suffering from rotator cuff tear. On the other hand the expression of these inflammatory cytokines and growth factors were little detected only to a small degree in patients with anterior shoulder instability who did not have severe shoulder pain and impingement in the subacromial space. Our findings suggest that those inflammatory cytokines and growth factors may play an important role in inflammation of the subacromial bursa. Controlling the expression of these cytokines and growth factors might be important for treating patients suffering from shoulder pain due to rotator cuff tear.
影响因子：
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作者：
L. Crofford
通讯作者：
L. Crofford