Fundus Autofluorescence in Polypoidal Choroidal Vasculopathy
Fundus Autofluorescence in Polypoidal Choroidal Vasculopathy
复制标题
DOI：
10.1016/j.ophtha.2012.02.016
复制
发表时间：
2012-08-01
期刊：
影响因子：
13.7
通讯作者：
Kinoshita, Shigeru
中科院分区：
文献类型：
--
作者：
Yamagishi, Tetsuya;Koizumi, Hideki;Kinoshita, Shigeru
目的：研究和比较息肉状脉络膜血管病变（PCV）与典型新生血管性年龄相关性黄斑变性（AMD）的眼底自发荧光（FAF）特征。设计：回顾性、观察性、连续病例系列。参与者：92例PCV患者（92只受累眼和86只未受累对侧眼）和31例无典型脉络膜新生血管的典型新生血管隐匿性AMD患者方法：所有研究眼均使用基于眼底照相机的系统进行FAF摄影。结果：在PCV患者中，新生血管病变的部位表现为2种不同的FAF模式：1、FAF模式：2、FAF模式：1、FAF模式：3、FAF模式：1、FAF模式：2、FAF模式：3、FAF模式：1、FAF模式：3、FAF模式：（1）息肉样病变处的融合性低自体荧光和（2）分支脉络膜血管网处的颗粒状低自体荧光。PCV组74眼（80.4%）可见融合的低自体荧光，多数被高自体荧光环包围，而典型新生血管性AMD组无一例可见融合的低自体荧光（P < 0.001）。PCV组91眼（98.9%）和典型新生血管性AMD组27眼（87.1%）可见颗粒状低自发荧光（P = 0.014）。此外，PCV患者黄斑区外的低自发荧光较典型的新生血管性AMD患者更常见（P = 0.021）。在正常对照眼中，PCV组黄斑区和FAF图像上的低自发荧光较典型新生血管性AMD组明显增多（P = 0.012，P = 0.003）。结论：PCV组中，息肉样病变和脉络膜血管网络的分支影响RPE，并导致特殊的FAF表现。当与典型的新生血管性AMD患者相比，广泛的RPE损伤更频繁地观察到PCV患者，无论是在受影响的眼睛和未受影响的fellow eyes.Financial披露（S）：作者没有专有或商业利益在本文中讨论的任何材料。Ophthalmology 2012;119：1650-1657（C）2012，美国眼科学会。
Purpose: To investigate and compare the characteristics of fundus autofluorescence (FAF) in polypoidal choroidal vasculopathy (PCV) with those in typical neovascular age-related macular degeneration (AMD).Design: Retrospective, observational, consecutive case series.Participants: Ninety-two patients with PCV (92 affected eyes and 86 unaffected fellow eyes) and 31 patients with typical neovascular occult AMD with no classic choroidal neovascularization (31 affected eyes and 24 unaffected fellow eyes).Methods: All study eyes underwent FAF photography with a fundus camera-based system. The incidence and distribution of hypoautofluorescence, that is, the manifestation of retinal pigment epithelium (RPE) damages, were evaluated.Main Outcome Measures: The characteristic FAF findings in PCV.Results: In the affected eyes with PCV, the sites of the neovascular lesions showed 2 distinct FAF patterns: (1) the confluent hypoautofluorescence at the polypoidal lesions and (2) the granular hypoautofluorescence at the branching choroidal vascular networks. The confluent hypoautofluorescence, most of which was surrounded by a hyperautofluorescent ring, was seen in 74 eyes (80.4%) with PCV but was seen in no eyes with typical neovascular AMD (P < 0.001). The granular hypoautofluorescence was seen in 91 eyes (98.9%) with PCV and 27 eyes (87.1%) with typical neovascular AMD (P = 0.014). In addition, the eyes with PCV more frequently showed hypoautofluorescence outside the macular area than those with typical neovascular AMD (P = 0.021). In the unaffected fellow eyes, the hypoautofluorescence was more frequently observed in patients with PCV than in those with typical neovascular AMD, inside the macular area and in the entire FAF image (P = 0.012, P = 0.003, respectively).Conclusions: In eyes with PCV, the polypoidal lesions and the branching choroidal vascular networks appeared to affect the RPE and induce peculiar FAF findings. When compared with the patients with typical neovascular AMD, widespread RPE damage was more frequently observed in the patients with PCV, both in the affected eyes and in the unaffected fellow eyes.Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2012;119:1650-1657 (C) 2012 by the American Academy of Ophthalmology.