SINGLE-DOSE KINETICS OF NIFEDIPINE IN RAT PLASMA AND BRAIN
SINGLE-DOSE KINETICS OF NIFEDIPINE IN RAT PLASMA AND BRAIN
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DOI：
10.1159/000138382
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发表时间：
1988-03-01
期刊：
影响因子：
3.1
通讯作者：
KRZASCIK, P
中科院分区：
文献类型：
--
作者：
JANICKI, PK;SIEMBAB, D;KRZASCIK, P
大鼠静脉注射硝苯地平6 mg/kg体重后5min~4h测定血浆和脑组织中硝苯地平的浓度。用二氯甲烷-戊烷混合液在钠光下提取大鼠血浆和脑组织匀浆样品。采用反相C18色谱柱，电化学检测，高效液相色谱法进行分析。硝苯地平10分钟后在脑内的峰值浓度为37微克/克湿重组织，半衰期为75分钟。显然，硝苯地平可以很容易地穿过大鼠的血脑屏障。
Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 mg/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethane-pentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 .mu.g/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.