Altered immune responses in mice with concomitant Schistosoma mansoni and Plasmodium chabaudi infections
Altered immune responses in mice with concomitant Schistosoma mansoni and Plasmodium chabaudi infections
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DOI：
10.1128/iai.66.11.5167-5174.1998
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发表时间：
1998-11-01
影响因子：
3.1
通讯作者：
Troye-Blomberg, M
中科院分区：
文献类型：
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作者：
Helmby, H;Kullberg, M;Troye-Blomberg, M
混合性寄生虫感染在世界许多地区很常见。然而，关于并发感染如何影响彼此的免疫和/或发病机制，我们知之甚少。抗药小鼠血期chabaudi疟原虫的保护和消除是通过CD4(+) Th1和Th2细胞的顺序激活来实现的。曼氏血吸虫小鼠模型的未成熟产蛋阶段与对血吸虫和不相关抗原的强烈Th2反应有关。在这项研究中，我们研究了感染曼氏沙门氏菌的小鼠如何影响对恰波迪疟原虫感染的免疫反应和发病机制。感染曼氏梭菌8周的C57BL/6小鼠感染血期夏氏梭菌。这些小鼠体内的疟原虫明显高于仅感染恰波迪疟原虫的小鼠。在双感染小鼠中，脾脏细胞增殖和Th2对mansoni可溶性卵抗原（SEA）或抗cd3的反应在疟疾感染后1个月被抑制。sea特异性免疫球蛋白M （IgM）和IgG血清抗体水平相似。对恰布地虫诱导的γ干扰素反应有显著影响。然而，在双重感染小鼠中，肿瘤坏死因子α (tnf - α)的产生明显降低。因此，TNF-LU产生的缺陷可能是曼氏疟原虫疟原虫数量增加的原因之一。chabaudi-infected老鼠。综上所述，我们的数据表明，血吸虫病和疟疾感染会深刻地相互影响，这些发现可能会对疫苗的开发产生影响。
Mixed parasitic infections are common in many parts of the world. However, little is known about how concurrent infections affect the immunity to and/or pathogenesis of each other. Protection and elimination of blood-stage Plasmodium chabaudi chabaudi AS in resistant mice are characterized by a sequential activation of CD4(+) Th1 and Th2 cells. The patent egg-laying stage of the murine model of Schistosoma mansoni is associated with a strong Th2 response to both Schistosoma and unrelated antigens. fn this study, we investigated how infection of mice with S. mansoni would affect the immune response to and pathogenesis of a P. chabaudi infection. C57BL/6 mice infected with S. mansoni for 8 weeks were infected with blood-stage P. chabaudi. Malaria parasitemias were significantly higher in these mice than in mice infected with P. chabaudi only. In doubly infected mice, both spleen cell proliferative and Th2 responses to S. mansoni soluble egg antigen (SEA) or anti-CD3 were suppressed up to 1 month after the malaria infection. Findings for SEA-specific immunoglobulin M (IgM) and IgG serum antibody levels were similar. Nb significant effects mere seen on P. chabaudi-induced gamma interferon responses. However, tumor necrosis factor alpha (TNF-alpha) production was significantly lower in double-infected mice. Thus, a defect in TNF-LU production might contribute to the increased malaria parasitemias seen in S. mansoni-P. chabaudi-infected mice. Taken together, our data show that schistosoma and malaria infections profoundly affect each other, findings which might have implications for the development of vaccines.