Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression.
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression.
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DOI：
10.1186/1750-2187-2-2
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发表时间：
2007-02-26
影响因子：
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通讯作者：
Wong, Yung H
中科院分区：
文献类型：
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作者：
New, David C;Wong, Yung H
G蛋白偶联受体是细胞通讯的关键调节因子，介导细胞对细胞外刺激的反应的有效协调。当受到刺激时，这些受体调节广泛的细胞内信号传导途径的活性，这些信号传导途径促进生物体的有序发育、生长和繁殖。现在有越来越多的证据检查G蛋白偶联受体能够调节细胞周期调节蛋白的表达、活性、定位和稳定性的机制，所述细胞周期调节蛋白促进或抑制DNA合成的起始。在这篇综述中，我们将详细介绍介导G蛋白偶联受体调节细胞增殖的细胞内途径，特别是从G1期到S期的细胞周期的进展。
G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli. When stimulated these receptors modulate the activity of a wide range of intracellular signalling pathways that facilitate the ordered development, growth and reproduction of the organism. There is now a growing body of evidence examining the mechanisms by which G protein-coupled receptors are able to regulate the expression, activity, localization and stability of cell cycle regulatory proteins that either promote or inhibit the initiation of DNA synthesis. In this review, we will detail the intracellular pathways that mediate the G protein-coupled receptor regulation of cellular proliferation, specifically the progression from the G1 phase to the S phase of the cell cycle.