Primordial odontogenic tumor: Subepithelial expression of Syndecan-1 and Ki-67 suggests origin during early odontogenesis.
Primordial odontogenic tumor: Subepithelial expression of Syndecan-1 and Ki-67 suggests origin during early odontogenesis.
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原始牙源性肿瘤：Syndecan-1 和 Ki-67 的上皮下表达提示起源于早期牙源性肿瘤。
DOI：
10.1111/odi.12733
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发表时间：
2018
期刊：
影响因子：
3.8
通讯作者：
Mosqueda-Taylor A.
中科院分区：
文献类型：
--
作者：
Bologna-Molina R;Mikami T;Pereira-Prado V;Tapia-Repetto G;Pires FR;Carlos R;Mosqueda-Taylor A.
原发性牙源性肿瘤（primitive odontogenic tumor，POT）是由多细胞的粘液样结缔组织组成，周围包裹着立方至柱状的牙源性上皮，类似于成釉器的内上皮，常内陷到下层结缔组织中。肿瘤至少部分由薄的纤维囊界定。它起源于牙齿发育的早期阶段。Syndecan-1是一种硫酸乙酰肝素蛋白聚糖，在多种细胞功能中具有生理作用，包括维持上皮结构、细胞与细胞间粘附以及细胞与细胞外基质和多种生长因子的相互作用，刺激细胞增殖。Ki-67被认为是细胞增殖标志物的金标准。本研究的目的是检测Syndecan-1和Ki-67增殖指数在POT和正常牙胚中的表达，以更好地了解这种肿瘤的生物学行为。结果表明，Syndecan-1在POT的上皮下间充质区域表达更强烈，其模式类似于牙齿发育的早期阶段。细胞增殖指数（4.1%）表明POT是一种生长缓慢的肿瘤。Syndecan‐1在帽状晚期和钟状早期牙胚中的表达与POT相似，在上皮下间充质凝聚区显示免疫阳性。免疫组化结果显示，其中的人口上皮下间充质细胞表现出更大的增殖活性比中央部分的牙乳头。
Primordial odontogenic tumor (POT) is composed of variably cellular myxoid connective tissue, surrounded by cuboidal to columnar odontogenic epithelium resembling the inner epithelium of the enamel organ, which often invaginates into the underlying connective tissue. The tumor is delimited at least partially by a thin fibrous capsule. It derives from the early stages of tooth development. Syndecan‐1 is a heparan sulfate proteoglycan that has a physiological role in several cellular functions, including maintenance of the epithelial architecture, cell‐to‐cell adhesion and interaction of cells with extracellular matrix, and with diverse growth factors, stimulating cell proliferation. Ki‐67 is considered the gold standard as a cell proliferation marker. The aim of this study was to examine the expression of Syndecan‐1 and Ki‐67 proliferation index in POT and normal tooth germs to better understand the biological behavior of this tumor. Results showed that Syndecan‐1 was more intensely expressed in subepithelial mesenchymal areas of POT, in a pattern that resembles the early stages of tooth development. The cell proliferation index (4.1%) suggests that POT is a slow growing tumor. Syndecan‐1 expression in tooth germs in late cap and early bell stages was similar to POT, showing immunopositivity in subepithelial mesenchymal condensed areas. The immunohistochemical findings showed a pattern in which the population of subepithelial mesenchymal cells exhibited greater proliferative activity than the central portion of the dental papilla.