Child Weight Gain Trajectories Linked To Oral Microbiota Composition
Child Weight Gain Trajectories Linked To Oral Microbiota Composition
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DOI：
10.1038/s41598-018-31866-9
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发表时间：
2018-09-19
影响因子：
4.6
通讯作者：
Makova, Kateryna D.
中科院分区：
文献类型：
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作者：
Craig, Sarah J. C.;Blankenberg, Daniel;Makova, Kateryna D.
在肥胖的成年人和青少年中观察到肠道和口腔微生物群紊乱;关于它们对幼儿体重增加的影响知之甚少。在这里，我们用16 S rRNA基因测序分析了226名两岁奥尔兹的肠道和口腔微生物群。在七个时间点测量了体重和身长，并用于识别婴儿体重快速增加的儿童（儿童肥胖的一个强风险因素），并使用创新的功能数据分析（FDA）技术推导出生长曲线。我们发现，生长曲线与口腔微生物群的多样性呈负相关，与厚壁菌与拟杆菌的比例呈正相关。我们还证明了肠道微生物群与儿童生长之间的关联，即使在控制了饮食对微生物群的影响之后。最后，我们确定了几个与儿童生长模式相关的细菌属。这些结果表明，到两岁时，婴儿体重快速增加的儿童的口腔微生物群可能已经开始建立肥胖成年人常见的模式。他们还表明，两岁时的肠道微生物群虽然受到饮食的强烈影响，但并没有携带许多研究人员在以后的生活阶段发现的肥胖特征。
Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at seven time points and used to identify children with rapid infant weight gain (a strong risk factor for childhood obesity), and to derive growth curves with innovative Functional Data Analysis (FDA) techniques. We showed that growth curves were associated negatively with diversity, and positively with the Firmicutes-to-Bacteroidetes ratio, of the oral microbiota. We also demonstrated an association between the gut microbiota and child growth, even after controlling for the effect of diet on the microbiota. Lastly, we identified several bacterial genera that were associated with child growth patterns. These results suggest that by the age of two, the oral microbiota of children with rapid infant weight gain may have already begun to establish patterns often seen in obese adults. They also suggest that the gut microbiota at age two, while strongly influenced by diet, does not harbor obesity signatures many researchers identified in later life stages.