Mechanical and electrical activity of esophageal smooth muscle during peristalsis.
Mechanical and electrical activity of esophageal smooth muscle during peristalsis.
复制标题
蠕动过程中食管平滑肌的机械和电活动。
DOI：
10.1152/ajpgi.1984.246.2.g145
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Goyal,RK
中科院分区：
文献类型：
--
作者：
Sugarbaker,DJ;Rattan,S;Goyal,RK
机械事件和膜电位的变化，诱发吞咽和颈部迷走神经刺激（10和40 Hz）记录在麻醉负鼠。微型应变传感器监测两层的机械活动。抽吸电极记录完整食管、纵肌（LM）近端蒂瓣和环行肌（CM）。吞咽的开始以下颌舌骨活动的开始为标志。吞咽时LM收缩先于CM收缩，持续时间较长。LM和CM收缩的延迟分别为1，980 +/- 38和2，250 +/- 101 ms。LM和CM的收缩持续时间分别为5，590 +/- 260和3，330 +/- 67 ms。LM显示无超极化，但显示去极化和锋电位爆发。CM表现为迅速超极化，随后是去极化和锋电位爆发。对迷走神经刺激的反应在性质上与吞咽相似。通过改变刺激频率，对反应的不同成分进行定量修改。这些研究表明，在吞咽和迷走神经刺激引起的舒张期间，1）LM收缩发生在CM之前，持续时间较长，2）与CM不同，LM在去极化之前不会过度舒张。
Mechanical events and membrane potential changes in response to evoked swallows and cervical vagal stimulation (10 and 40 Hz) were recorded in anesthetized opossums. Miniature strain-gauge transducers monitored the mechanical activity of the two layers. A suction electrode recorded from the intact esophagus, from a proximally based pedicle flap of longitudinal muscle (LM), and from circular muscle (CM). The onset of swallowing was marked by the onset of mylohyoid activity. During swallows LM contraction preceded CM contraction and was of longer duration. The latencies of LM and CM contraction were 1,980 +/- 38 and 2,250 +/- 101 ms, respectively. The durations of contraction of LM and CM were 5,590 +/- 260 and 3,330 +/- 67 ms, respectively. LM showed no hyperpolarization but showed depolarization and spike burst. The CM showed prompt hyperpolarization followed by depolarization and spike burst. Responses to vagal stimulation were qualitatively similar to swallows. The different components of the responses were quantitatively modified by changes in stimulus frequency. These studies show that, during peristalsis in response to swallows and vagal stimulation, 1) LM contraction occurs before CM and is of longer duration, and 2) unlike CM, LM does not hyperpolarize prior to depolarization.