Kinetics of rouleau formation. II. Reversible reactions.
Kinetics of rouleau formation. II. Reversible reactions.
复制标题
卷罗形成动力学。
DOI：
10.1016/s0006-3495(84)84225-3
复制
发表时间：
1984
影响因子：
3.4
通讯作者：
Perelson,AS
中科院分区：
文献类型：
--
作者：
Samsel,RW;Perelson,AS
红细胞面对面聚集形成长的、圆柱形的直链，有时还形成称为红细胞叠连的分支结构。在这里，我们扩展了由R。W. Samsel和A. S. Perelson（1982，Biophys. J. 37：493-514）以包括叠连的形成和解离。我们研究热力学约束的详细平衡的原则所施加的模型的速率常数。将逆反应，使我们能够计算平均大小的rouleaux和直链段内的rouleaux，作为时间的函数，并在平衡。使用高分子化学的Flory-Stockmayer方法，我们获得了反应演化过程中任意点处直链链段的尺寸分布的封闭解。我们的理论预测与D. Kernick，A.W.L. Jay，S. Rowlands和L. Skibo（1973，Can. J. Physiol. Pharmacol. 51：690-699）关于rouleau形成的动力学。当串叠变大时，它们可能包含环或回路，并呈现出网络的外观。我们证明了包括环闭合的动力学在发展中的现实模型的叠连形成的重要性。
Red blood cells aggregate face-to-face to form long, cylindrical, straight chains and sometimes branched structures called rouleaux. Here we extend a kinetic model developed by R. W. Samsel and A. S. Perelson (1982, Biophys. J. 37:493–514) to include both the formation and dissociation of rouleaux. We examine thermodynamic constraints on the rate constants of the model imposed by the principle of detailed balance. Incorporation of reverse reactions allows us to compute mean sizes of rouleaux and straight chain segments within rouleaux, as functions of time and at equilibrium. Using the Flory - Stockmayer method from polymer chemistry, we obtain a closed-form solution for the size distribution of straight chain segments within rouleaux at any point in the evolution of the reaction. The predictions of our theory compare favorably with data collected by D. Kernick , A.W.L. Jay , S. Rowlands , and L. Skibo (1973, Can. J. Physiol. Pharmacol. 51:690–699) on the kinetics of rouleau formation. When rouleaux grow large, they may contain rings or loops and take on the appearance of a network. We demonstrate the importance of including the kinetics of ring closure in the development of realistic models of rouleaux formation.