COMPARISON OF GAMMA-RAY-INDUCED CHROMOSOME RING AND INVERSION FREQUENCIES
COMPARISON OF GAMMA-RAY-INDUCED CHROMOSOME RING AND INVERSION FREQUENCIES
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DOI：
10.2307/3579154
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发表时间：
1995-08-01
影响因子：
3.4
通讯作者：
BEDFORD, JS
中科院分区：
文献类型：
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作者：
MUHLMANNDIAZ, MC;BEDFORD, JS
用一种方法检测人G（0）细胞γ射线照射后第一次有丝分裂中的明显或假姐妹染色单体交换（SCE）的染色体倒位。小反转的剂量-反应关系尚未被测量和报告，但它已被假定，这些诱导的频率等于其容易测量的不对称对应物，间隙缺失。我们的实验证实了这一预期。正如其他人所建议的，结果也表明，在先前的细胞周期中，在BrdU掺入后的第一次辐射后有丝分裂中报告了SCE的方案中，X射线或γ射线处理G（0）或G（1）期细胞实际上不产生真正的SCE。(C)1995年，辐射研究学会
A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after gamma irradiation of human G(0) cells. Dose-response relationships for small inversions have not been measured and reported previously, but it has been assumed that these are induced with a frequency equal to that of their easily measured asymmetrical counterpart, the interstitial deletion. Our experiments confirm this expectation. The results also demonstrate, as others have suggested, that in protocols where SCEs have been reported in the first postirradiation mitosis after incorporation of BrdU in the previous cell cycle, the X- or gamma-ray treatment of G(0)- or G(1)-phase cells produces virtually no true SCEs. (C) 1995 by Radiation Research Society