Risk factors for mortality among COVID-19 patients
Risk factors for mortality among COVID-19 patients
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DOI：
10.1016/j.diabres.2020.108293
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发表时间：
2020-08-01
影响因子：
5.1
通讯作者：
Ghadzi, Siti Maisharah Sheikh
中科院分区：
文献类型：
--
作者：
Albitar, Orwa;Ballouze, Rama;Ghadzi, Siti Maisharah Sheikh
目标：COVID-19是当前的全球大流行。然而，缺乏对其死亡危险因素的全面全球数据分析。目前的调查旨在从全球开放获取数据中评估COVID-19患者的死亡预测因素。方法：从开放获取的全球个人数据中回顾性地筛选出828例具有明确结局的COVID-19确诊病例。采用单因素和多变量回归分析评估潜在危险因素与死亡率之间的关系。结果：患者以男性居多（59.1%），亚洲地区占69.3%。根据数据，老年人(调整优势比（aOR）， 1.079；95%可信区间（95% CI），每年增加1.064-1.095)、男性（aOR, 1.607; 95% CI, 1.002-2.576）、高血压患者（aOR, 3.576; 95% CI, 1.694-7.548）、糖尿病患者（aOR, 12.234; 95% CI, 4.126-36.272）和美国患者（aOR, 7.441; 95% CI, 3.546-15.617）被确定为COVID-19患者死亡的危险因素。结论：男性、高龄、高血压患者、糖尿病患者和美国患者是COVID-19患者死亡的独立危险因素。需要特别注意这些因素，并对这些影响的潜在机制进行进一步的研究。(C) 2020 Elsevier B.V.版权所有
Aims: COVID-19 is a current global pandemic. However, comprehensive global data analyses for its mortality risk factors are lacking. The current investigation aimed to assess the predictors of death among COVID-19 patients from worldwide open access data.Methods: A total of 828 confirmed cases of COVID-19 with definite outcomes were retrospectively identified from open access individual-level worldwide data. Univariate followed by multivariable regression analysis were used to evaluate the association between potential risk factors and mortality.Results: Majority of the patients were males 59.1% located in Asia 69.3%. Based on the data, older age (adjusted odds ratio (aOR), 1.079; 95% confidence intervals (95% CI), 1.064-1.095 per year increase), males (aOR, 1.607; 95% CI, 1.002-2.576), patients with hypertension (aOR, 3.576; 95% CI, 1.694-7.548), diabetes mellitus (aOR, 12.234; 95% CI, 4.126-36.272), and patients located in America (aOR, 7.441; 95% CI, 3.546-15.617) were identified as the risk factors of mortality among COVID-19 patients.Conclusions: Males, advanced age, hypertension patients, diabetes mellitus patients, and patients located in America were the independent risk factors of death among COVID-19 patients. Extra attention is required to be given to these factors and additional studies on the underlying mechanisms of these effects. (C) 2020 Elsevier B.V. All rights reserved.